Evodiae Fructus is the dried unripe fruit of Evodia rutaecarpa, and has traditionally been used for treating stomachache and diarrhea. Evodiamine and rutaecarpine, the major biologically active compounds of Evodiae Fructus, are reported to have anti-oxidative and anti-inflammatory effects, as well as inhibit proliferation and metastasis of various cancer cells. The current study investigates the anti-oxidative and anti-cancer effects of the Evodiae Fructus extract, considering varying concentrations of methanol extraction (40, 80, and 95%). High contents of total phenolic compounds were determined in the order of extracts 80, 95, and 40%. Evaluating contents of the 95, 80, and 40% extracts revealed 36.77, 7.29, and 1.86 μg/mg evodiamine, respectively, and 53.02, 17.16, and 3.79 μg/mg rutaecarpine, respectively, with the highest content of both compounds obtained in the 95% extract. DPPH radical scavenging activity was observed to be inversely proportional to the contents of total phenolic compounds, with decreasing SC50 values obtained in the order 80, 95, and 40% extract. The 95 and 80% extracts exerted toxicity to AGS gastric cancer cells, but the 40% extract was non-toxic. Evodiamine is a known anti-cancer agent, and could be responsible for the observed toxicity. Cleavage of PARP, and Caspase-3, -7, -8 and -9 was observed in the 95% extract-treated AGS cells, indicating that cell toxicity exerted by the 95% extract could be attributed to apoptosis.

이 논문은 대학생 독서 프로그램을 개발하기 위한 목적으로 작성한 것이다. 교양 교과목에서 슬로리딩 즉 천천히 읽기 방법으로 한 학기에 한 권을 완독한다는 목표를 모두가 달성하도록 하였다. 그로써 대학생 학습자의 독서에 대한 관심을 불러일으키고, 완료 형태의 독서 경험을 바탕으로 다른 독서로 옮겨 가는 바람직한 방향성을 제시하고자 하였다. 책을 천천히 자세히 읽는 활동과 동시에 짝과의 토론을 통해 이해 하지 못한 어려운 부분을 해결함으로써 미진함이 남지 않도록 주의했다. 이 독서교육은 책을 읽고 감상문 을 쓰면 특정 점수를 얻거나 마일리지를 쌓는 방식으로 결과에 초점을 둔 방식이 아닌 읽는 과정에 중점을 두고 운영하는 과정중심 독서교육 프로그램이기에 내적 동기를 유발할 수 있다는 차별점 및 특수성이 있다. 이 경험을 활용하여 대학생 독자 스스로가 자신의 독서 습관을 점검하고 이후의 독서 계획을 세울 수 있다는 것이 이점이다.

Background: Weakness of the abdominal and mid thoracic muscles the lead to thoracic kyphosis of stroke patients. The trunk muscles activity of stroke patients is significantly related to upper extremity. Objectives: To investigate the effect of seated exercise of thoracic and abdominal muscles on upper extremity function and trunk muscles activity in stroke patients. Design: One-group pretest-posttest design. Methods: A total of 27 stroke patients were recruited. All stroke patient were given seated abdominal exercise (posterior pelvic tilt exercises) and thoracic exercise (postural-correction exercise). All exercises were conducted for 30 minutes, three times a week for four weeks. The manual function test (MFT) and electromyography (EMG) were measured, and EMG electrodes were attached to thoracic paraspinal muscles and lower rectus abdominal muscles. EMG signal is expressed as %RVC (reference voluntary contraction). Results: Experimental group showed significant increases in abdominal muscles, paraspinal muscles activity and MFT total score, items of arm motion (forward elevation of the upper extremity, lateral elevation of the upper extremity, touch the occiput with the palm) in MFT after four weeks. Conclusion: These results suggest that, in stroke patients, seated exercise of thoracic and abdominal muscles contribute to improve trunk muscles activity and upper extremity function in stroke patients.

Background: Previous robot-mediated gait training has been proven several limitations such as pointless repeated motion training, decreased presence, etc. In this research, adult stroke patients were participated in robot-mediated gait training accompanied with or without virtual reality program. Objectives: Exploring whether the results indicated virtual reality system has contribution to muscle strength and balance ability. Design: A case series research, cross-over trial. Methods: Eleven participants (male 4, female 7) with adults diagnosed as stroke from medical doctor ware engaged. The participants received 2 treatment sessions of identical duration, robot-assisted gait training with virtual reality and robot-assisted gait training with screen-off randomly crossed over include 1-day for each person of wash-out period. The parameter was muscle activity, the researchers assessed sEMG (surface electromyography). Results: The result showed less muscle activities during training in robotassisted gait training with virtual reality circumstances, and these indicated muscles were gluteus medius muscle, vastus medialis muscle, vastus intermedius and vastus lateralis muscle, semimembranosus muscle, gastrocnemius- lateral head, and soleus muscle (P<.05). Conclusion: In this study, we analyzed the outcome of muscle activity for clinical inference of robot-assisted gait training with virtual reality (VR). Less muscle activity was measured in the treatment accompanied by VR, therefore, a more systematic, in-depth and well-founded level of follow-up research is needed.

목적 : 항산화 기능을 가지는 하이드로겔 콘택트렌즈(Hy)를 제조하기 위해 갈릭산(Gallic acid: GA)을 Hy에 상 분리 없이 도입시키는 방법에 관해 연구하고, 갈릭산이 첨가된 렌즈의 물리적 특성 및 항산화 효과를 살펴보고 자 한다. 방법 : 하이드로겔 콘택트렌즈는 실험실에서 열중합방법으로 제조하였다. 갈릭산과의 결합을 위해 사용된 Chitosan(Cs) 은 100~300 kDa(CL), 600~800 kDa(CH) 분자량을 가진 두 종류를 사용하였으며, Hy에 IPN(Interpenetrating polymer network) 방법으로 첨가하였다. 광 투과율은 300~800 nm 파장 범위에서 측정하였으며, 함수율은 중량 법으로 측정하였다. 키토산과 갈릭산 간의 amide bonding은 FT-IR을 이용하여 확인하였으며, 첨가된 갈릭산의 양 은 298 nm에서 측정한 UV 흡광도 값으로 정량하였다. 렌즈의 항산화 효과는 DPPH radical 소거능 분석 방법을 사용하였다. 결과 : 광 투과율은 Hy에서 95%, Hy-CL-GA와 Hy-CH-GA에서 91%를 보였다. 함수율은 Hy에서 50.5±1.2%, Hy-CL-GA에서 52.4±0.7%, Hy-CH-GA에서 55.6±0.6%로 나타났다. 렌즈에 결합된 갈릭산의 양은 Hy-CLGA와 Hy-CH-GA에서 0.30, 0.37 mmol/cm2로 각각 나타났으며, 항산화 효과는 Hy-CL-GA에서 48.23%, Hy- CH-GA에서는 58.32%로 나타나 갈릭산을 첨가한 두 렌즈에서 매우 높은 항산화 기능을 확인할 수 있었다. 결론 : 키토산과 갈릭산을 활용하여 광 투과율과 함수율이 높고 항산화 효과를 가진 기능성 하이드로겔 콘택트 렌즈를 제조하였다. 렌즈에 결합된 갈릭산의 양이 증가함에 따라 함수율과 항산화 효과가 증가하였다. 콘택트렌즈 에 다당류와 폴리페놀류의 화합물을 첨가하는 방법을 제시함으로써 단백질 억제, 습윤성 향상, 항산화 기능 등을 함유한 다 기능성 렌즈 제조에 기여할 것으로 본다.

The prickly pear cactus (Opuntia), native to Mexico, has grown in popularity and is locally grown and adapted on Jeju Island. The fruits of this cactus species are in particular widely employed as raw materials, which are then processed into various food and medicinal items, including chocolates and vitamins, for purposes of human consumption. Because this crop has been dubbed one of Jeju’s iconic agricultural crops, research studies elucidating the prickly pear cactus’ medicinal properties, including antioxidant activity, of this particular plant and related cultivated species have demonstrated high value to the scientific community. Currently, consumers do not purchase products f or c onsumption a lone, but in a ddition f or t heir added health benef its. The present study in particular honed in on two species of prickly pear cactus that are cultivated on Jeju Island which include: ‘Baeknyeoncho’ (Opuntia ficus-indica) and ‘Cheonnyeoncho’ (Opuntia humifusa). From these species, s pecif ci p lant p arts i ncluding t he f lower, mature and y oung stems, roots, a nd f ruit w ere subjected to further antioxidant analysis, which included the determination of polyphenol, flavonoid, DPPH radical, ABTS radical, and anthocyanin levels. These particular antioxidants were determined during two seasons, over the course of the summer and winter. Results revealed that the antioxidant activity for both species was more active during the summer season. Antioxidant levels occurred at the highest rates within t he flowers o f the c actus plants. However, of significant note was that the cactus stem, in both mature and young plants, possessed higher antioxidant activity compared to those of the fruit that is currently employed for commercial purposes.

본 연구는 여가활동으로서의 무도스포츠의 역할과 가치를 정립하기 위한 연구의 방향 설정을 위하여 선행연구를 검토하여 대안을 제시하는데 그 목적이 있다. 연구의 목적을 달성하기 위해 여가관련 학술지의 키워드, 주제 등을 추출하여 국내 학술지의 무도관련 연도별 논문과 현황을 SPSS 기술통계 방법을 사용하여 도출하였으며, 2016 국민생활체육 실태조사 보고서를 분석에 활용하였다. 분석대상은 2005년 부터 2017년 사이의 여가관련 학회지의 ‘무도’와 ‘여가’를 키워드로 수집하였으며, 개별 연구에 대한 내용을 분석하기 위하여 텍스트 분석(interpretative textual analysis)를 실시하였다. 분석결과 2016 국민생활체육 참여실태 조사보고서에 따르면 생활체육 중 강습경험이 있는 종목 중 태권도가 6.1%로 상위 5개 종목 중 5위로 나타났고, 학생들의 교외 체육활동 참여 종목과 향후 가입하고 싶은 동호회 역시 태권도와 검도 가 각각 1순위와 2순위로 확인되어 이미 무도스포츠는 생활스포츠로서 역할을 하고 있는 것으로 나타났다. 둘째, 여가관련 학회지의 무도관련 연구는 2006년과 2010년 각 3편씩으로 가장 많이 발견되었으나 2014 년 이후에는 단 한편의 연구도 수행되지 않은 것으로 나타나 절대적인 연구 편수는 매우 미흡한 것으로 확인되었다. 셋째, 여가관련 학회지의 연구 주제는 진지한 여가, 여자 대학생, 신체적 자기개념, 사회성 발달, 여가레크리에이션 수업, 직무만족, 생활만족, 수련, 여가제약 등으로 여가와 관련된 무도연구는 양적, 질적 으로 다각적인 접근이 필요한 것으로 나타났다. 넷째, 국내 학술지의 연도별 무도관련 연구 현황을 살펴보면 2007년 23편의 연구 중 2편이 여가를 주제로 수행한 것으로 나타났으며 국내 무도관련 연구와 여가관 련 논문 수의 평균은 5.65%로 그 비율이 매우 낮다. 결론적으로 무도스포츠로서의 여가를 주제로 한 연구의 동향을 분석한 결과 양적으로나 질적으로 개선을 통한 미래사회에서의 삶의 질과 행복감을 높일 수 있는 여가활동으로서의 무도스포츠의 역할과 가치를 재고할 수 있는 향후 연구의 방향을 제시할 필요가 있다.

The purpose of this study was to determine whether there are differences in the verbal interactions of earth science gifted depending on their communications structures and group status in small group activities. To this end, a small group activity was conducted to measure the density of the earth, and 8 small groups were selected, including 4 coownership type and 4 monopolistics type groups with different communication structures. And then, the framework was developed for analyzing verbal interactions to compare the differences in characteristics between small groups. The results are as follows. First, regardless of the communication structures, there were showing a simple pingpong-type communication structures for all small groups. Second, negative interactions such as ‘restraint’, ‘command’, ‘complaint’, and ‘lack of confidence’ predominantly appeared in all small groups. Third, the students in the status of out-lookers in small groups were mainly verbal interactions, such as instructing the other person, acting against the other person’s actions, and expressing dissatisfaction with the attitudes and abilities of members. Therefore, teachers should guide students to use higher-level verbal interactions in their group activities in small group activities, and engage in students communication to prevent negative interactions from occurring. The teachers also need to check the level of achievement for students in the status of out-lookers in advance and guide them to participate more actively in small group activities. This study is meaningful in that it can be sued to design teaching and learning to improve students’ problem solving and communication skills.

Bismuth vanadate (BiVO4) is considered a potentially attractive candidate for the visible-light-driven photodegradation of organic pollutants. In an effort to enhance their photocatalytic activities, BiVO4 nanofibers with controlled microstructures, grain sizes, and crystallinities are successfully prepared by electrospinning followed by a precisely controlled heat treatment. The structural features, morphologies, and photo-absorption performances of the asprepared samples are systematically investigated and can be readily controlled by varying the calcination temperature. From the physicochemical analysis results of the synthesized nanofiber, it is found that the nanofiber calcines at a lower temperature, shows a smaller crystallite size, and lower crystallinity. The photocatalytic degradation of rhodamine-B (RhB) reveals that the photocatalytic activity of the BiVO4 nanofibers can be improved by a thermal treatment at a relatively low temperature because of the optimization of the conflicting characteristics, crystallinity, crystallite size, and microstructure. The photocatalytic activity of the nanofiber calcined at 350oC for the degradation of RhB under visible-light irradiation exhibits a greater photocatalytic activity than the nanofibers synthesized at 400oC and 450oC.

The extracts of four species of ectomycorrhizal mushrooms—Cantharellus cinnabarinus (OK1247), Lactarius parallelus (OK1264), Tricholoma matsutake (OK1282), and Ramaria botrytis (OK1283)—were prepared to determine their antioxidant activities and nutritional properties. R. botrytis extract displayed the highest 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (33.8%), ferric reducing antioxidant power (0.38), reducing power (0.35), total polyphenol (13.83 mg gallic acid equivalent/g), and flavonoid contents (2.56 mg quercetin equivalent/g). L. parallelus extract displayed the highest nitrite scavenging activity. Analysis of amino acid contents revealed that C. cinnabarinus extract had the highest total amino acid (1,046.1 mg/kg) and essential amino acid (404.9 mg/kg) contents, while R. botrytis extract had the lowest total amino acid (708.3 mg/kg) and essential amino acid (247.3 mg/kg) contents. Among the amino acid components detected in the four ectomycorrhizal mushrooms, cysteine was the most abundant, accounting for 14.3~20.7%, followed by phenylalanine, which accounted for 9.5 ~13.4% of all amino acids. In summary, the antioxidant activities were the highest in R. botrytis extract, and the amino acid content was the highest in C. cinnabarinus extract, among the four ectomycorrhizal mushrooms.

목적 : 작업치료가 지적 장애 아동 및 청소년의 ADL과 참여에 미치는 효과에 대한 문헌고찰을 통해 지적 장애 아동을 위한 효과적인 중재와 치료의 근거를 마련하고자 한다. 연구방법 : Pubmed, Medline, KISS, RISS 등을 사용하여 2008년부터 2019년 사이에 출판된 논문을 검 색했다. 주요 검색어로 ‘intellectual disability’, ‘intervention’, ‘activity of daily living’을 사용하였고, 총 9편의 국내외 논문을 선정했다. 결과 : 연구에는 지역사회 기반 작업치료, 전산화 인지 프로그램, Co-PID와 같은 다양한 방법의 중재가 사용되었으며, 모든 중재는 ADL 또는 참여 향상에 유의미한 효과가 있었다. ADL 영역에서는 의사소통 기술, 작업수행기술, 식사 기술, 시지각 기술, 사회행동기술, 시간관리 기술 등에 유의미한 효과를 보였 다. 참여 영역에서는 의사소통, 선택하기, 학교관련 참여기술을 증진시켰다. 결론 : 본 연구에서는 지적장애 아동 및 청소년의 일상생활활동과 참여 수준을 향상시킨 작업치료 분야의 유의미한 중재들을 제시했다. 향후 연구의 질적 수준과 변수의 다양성을 고려하면서 지적장애 아동 및 청소년의 재활 중재를 위한 깊이 있는 연구가 더 이루어져야 할 것으로 사료된다.

This paper develops a risk index based on an indicator of risk assessment in terms of coastal activity location and accident type. The risk index is derived from a formula which adds the consequence of failure to a vulnerability value, then subtracts the mitigation value. Specifically, the consequence of failure is the number of casualties in coastal activity locations. An indicator of vulnerability refers to coastal environment elements and social elements. A pointer of mitigation includes managerial and organizational elements that indicate the capabilities of coastal activities. A risk rating of coastal activity location is found from a risk matrix consisting of the accident location and type. The purpose of this study is to prevent accidents at coastal activity locations by allowing the Coastal police guard to monitor effectively and inform visitors of potential risks.