본 연구는 함초를 섭취한 동물쥐에서 비만과 혈중 지질의 개선 효과에 대한 실험을 체계적 문헌고찰을 통해 통계적으로 분석하였다. 각각의 개별 연구는 PubMed, Embase, RISS, DBpia, NDSL과 같은 데이터베이스로부터 수집되었다. 통계분석을 통해 효과크기를 측정하기 위해 Review Manager 5.3 프로그램이 이용되었고 총 9개의 연구가 최종적으로 포함되었다. 비만유발 흰쥐에서 함초의 섭취는 몸 무게를 유의적으로 감소시켰다. 그러나, 식이효율, 간지수와 총콜레스테롤에서 통계적 유의성이 없었다. 또한, 효과크기가 중성지방은 감소하고, 고밀도 콜레스테롤은 증가하였다. 이러한 통계적 분석은 함초가 강력한 항비만과 혈중 지질 개선 효과를 가진다는 결과는 보여준다.

The main purpose of this study was to examine the correlation between the consumption of red ginseng-based ‘SSR’ for 30 days and the reduction in human fatigue, blood component changes, and immune cell activity in 35 human subjects. ‘SSR’ is composed of zinc oxide, folic acid, and D-α-tocopherol with red ginseng as the main component. According to the protocol criteria of the study, 35 subjects who understood the purpose of the study and signed an informed consent form were selected. The fatigue survey was conducted through a questionnaire, and after taking ‘SSR', a decreased tendency of physical, mental, and neurosensory fatigue was observed. In hematological analysis, no significant changes were observed in the levels of WBC, RBC, and hemoglobin; however, AST (SGOT) and ALT (SGPT) levels were statistically significantly decreased. In immunological analysis, it was observed that the proliferative effect of T cells (CD3+CD4+) was greater than that of NK cells (CD16+CD56+). The collected data were subjected to t-test analysis using the SPSS 25.0 statistical program. The result from this study proposes that ‘SSR’ can be used as a functional food material as it reduces human fatigue and enhances immune function.

General blood tests and leukocyte differential count are very useful in diagnosing, treating and managing patient’s diseases. This study was conducted to reduce errors caused by the manual method as much as possible by using an automated hematology analyzer (Sysmex K-4500), and to alleviate work burden of the laboratory. The T1 and T2 values calculated from leukocyte differential count that was obtained from the automated hematology analyzer Sysmex K-4500, and the results measured from the manual method were compared and analyzed by using the blood samples of 400 patients who were commissioned in the diagnostic laboratory of the hospital with 120 beds. Upon the results of the study, T1 and T2 obtained from lymphocyte differential count of the automated hematology analyzer Sysmex K-4500 demonstrated high correlation compared to manual method, and the analysis of monocyte, eosinophil, basophil and band cell obtained from T1, T2 and manual method enabled percentile calculation, even though it was difficult to predict the exact monocyte, eosinophil, basophil and band cell. Therefore, it is regarded that the optimal patient results can be reported if manual method observation is selectively combined while referring to T1 and T2 obtained from lymphocyte differential count of the automated hematology analyzer Sysmex K-4500.

This study, analyzed the general and minerals composition of kamut and investigated its effect on blood components in mice fed a high fat diet. The content of each general component of kamut was as follows: 11.02±0.75% water, 13.16 ±1.28% crude protein, 1.85±0.19% crude fat, and 1.97±0.13% ash. The leptin level was the highest in the HF group(30.00± 0.00 ng/mL) when compared to the control group. There was a significant decrease of 23.65±5.54 ng/mL in the HFK group when compared to the HF group (p<0.05). The blood LDL-cholesterol concentration was the lowest in the control group at 10.00±2.00 mg/dL. The level was highest in the HF group at 28.00±0.00 mg/dL when compared with the other groups (p<0.05). The aspartate transaminase (AST) level was significantly higher in the HFK group (179.33±173.88 U/L) than in the control (61.00±12.73 U/L) and HF groups (132.00±0.00 U/L). According to the results of this study, the consumption of kamut lowers the blood LDL-cholesterol level more than the consumption of wheat flour. Additionally, kamut contains antioxidant substances such as selenium and zinc, which are thought to contribute to vascular health and thus aid in maintaining good health. Therefore, it is necessary to develop a variety of health foods using kamut; it should be used as a functional food for the maintenance of good health.

This study investigated the stress-related metabolites and hormones in blood and compared the muscle structure to identify the reason for blood splash in Hanwoo beef. Five slaughter houses were selected based on the region (Seoul, Gimhae, Jungbu, Naju, and Goryung) and a previous blood splash record. In total, three-hundred eighty blood samples (n=380) and forty-two muscle tissues (n=42) of control and blood splash Hanwoo beef were collected during the slaughter process and beef grading. Blood metabolites were analyzed including glucose, lactate, creatinine, urea-N, and hormones such as cortisol and thyroxin. Muscle fiber, fiber bundle, and capillary wall thickness were measured under microscope. The concentrations of blood glucose, lactate, and urea-N were not significantly different between the control and the blood splash samples. Cortisol and thyroxin levels were not significantly different in both samples. In contrast, the creatinine level was significantly increased (p<0.05) in the blood splash samples. There were also no significant differences observed in muscle fiber, bundles, and capillary wall thickness between the control and the blood splash tissues. In conclusion, blood metabolites, hormones, and muscle fiber showed no differences between the control and the blood splash animal. However, increased creatinine levels may be used as an indicator for identifying blood splash prior to slaughter in Hanwoo.

혈청을 이용한 분석은 다양한 질병 진단의 지표로 이용 된다. 혈청의 분리 방법, 저장시간 및 온도에서 부적절한 혈액 처리는 사이토카인의 농도와 생화학 검사결과에 영 향을 줄 수 있다. 본 연구에서는 한우를 공시하여 혈청 분 리 시기, 저장 시간과 온도가 사이토카인 및 생화학 검사 결과에 미치는 영향을 조사 하였다. 혈액은 경정맥에서 채 취하여, 26±3℃에서 1~2시간 방치 후 분리조건을 다음과 같이 4개의 그룹 (a-d)으로 나뉘어 진행하였다. a) 혈청 분 리하여 보관(대조구), b) 혈청분리 후 아이스박스 2시간 방 치 후 보관, c) 아이스박스 2시간 방치 후 혈청분리, d) 24 시간 4℃ 방치 후 혈청분리, 이러한 조건으로 분리된 혈청 은 분석 전까지 –70℃ 보관 하였다. 혈청 분리시기, 아이스 박스 또는 4℃ 저장 시간 및 온도에 따라 IFN-γ는 유의적 인 차이를 보이지 않았고, TNF-α의 농도는 그룹 a-c에 비 해 그룹 d에서 유의적(p<0.05)으로 낮아졌다. 또한 albumin, total protein의 농도는 그룹 a보다 d에서 유의적 (p<0.01)으로 높았고, magnesium, calcium에서도 유사한 결과를 보였다(p<0.05). 그러나 G-GTP의 경우 다른 그룹에 비해 그룹 d에서 유의적(p<0.05)으로 가장 낮아졌다. 그러 므로 시료채취 시 농가와 실험실의 거리를 고려하여 온도와 저장시간이 혈청 내 사이토카인 및 생화학 농도에 미치 는 영향을 최소화 하여 연구 수행을 진행해야 될 것으로 사료된다.

This study aimed to investigate the effect of acorn powder and starch on the blood parameters of mice fed a high-fat diet. The moisture, crude ash, crude protein, and crude fat contents of acorns were 37.99±0.37%, 1.61±0.06%, 4.36±0.18% and 3.22±0.15%, respectively. Acorn powder and starch contains antioxidant minerals such as selenium and zinc. The iron content was significantly higher in acorn powder than in acorn starch (p<0.05). The total cholesterol concentration was 148.50±29.72 mg/dL in the high-fat starch diet (HFS) group, while in the high-fat diet (HF) group it was 201.50±39.15 mg/dL (p<0.05). Serum LDL-cholesterol concentrations were significantly lower in the HFS group (50.50±10.79 mg/dL) than in the HF group (62.00±20.85 mg/dL; p<0.05). The serum IL-1β levels in mice were not significantly different between the groups. IL-10 levels were higher in the HFP group than other groups. There is a need for strong recognition that acorns are good ingredients worldwide. It is required to develop various products using acorn powder and starch powder. There is also a need for a strategy to globalize food using acorns.

The objective of this research was to evaluate the effects of two different feeding systems on blood metabolites in Holstein heifers and analyze the economic impacts of the feeding systems. The following two experiments were conducted to investigate the effects of feeding system on blood metabolite changes in Holstein heifers and analyze the economic impacts of the two systems. In experiment 1, the effects of two different feeding systems on cortisol, progesterone, and estradiol in Holstein heifers were examined. In experiment 2, the effects of two different feeding systems on the body weights of Holstein heifers and profitability of the two feeding systems were studied. Results showed that the pasture-raised heifers showed significantly decrease in the levels of blood cortisol (p<0.05) and increases in the levels of progesterone and estradiol (p>0.05) when compared with heifers raised in indoor feeding system. The average daily gain was significantly higher (p<0.05) in indoor-raised heifers (0.73 kg/day) as compared to pasture-raised heifers (0.58 kg/day). Also, 25.2% more profits were obtained from the pasture feeding system as compared to the indoor feeding system. These results together would be useful in the investigation of feeding system and growth performance in dairy cattle.

The purpose of this study was to investigate the relations between HbA1c level and health risk factor. For analysis, 330 elderly women aged 65 years and over were recruited in Jeonla province, Korea. The subjects were classified into two groups according to their HbA1c level; the diabetic group (HbA1c level≥6.5%, n=68, 20.6%) and control group (HbA1c level< 6.5%, n=262, 79.4%). Demographic characteristics were collected, as well as information on physical measurements, blood tests for biochemical indicators, a health status and health-related life style, dietary behavior, favorite food groups, consumption frequency of food groups and nutrient intake. Educational level of the diabetic group was significantly lower than that of the control group. The height of the diabetic group was shorter, and percentage fat of the diabetic group was higher than those of the control group. In the diabetic group, the higher concentrations of creatinine and activity of alkaline phosphatase were found to be significantly unfavorable factors. Therefore, the diabetic group was assumed to be at risk of decreased liver and renal function. The self-rated health level of the diabetic group has a declining tendency, while the medicine intake was significantly higher than that of the control group, but there are no significant differences in visiting frequency of hospital and community health center. The distribution of physical activity showed a significant difference between the groups. Although there are no significant differences in nutrient intake, the diabetic group had relatively inferior nutrient intake of diet, especially vitamin C, as contrasted with the control group. In conclusion, the weight control and increasing physical activity may be effective in the prevention of the diabetes and continuous education and intervention by specialized nutritionists will be needed for diabetic patients. These results could be useful to plan effective strategies to increase the health-life expectancy and the prevention of the diabetes of Korean elderly people living in rural areas.

In photobiophysics, biophoton means a kind of biological energy which enhances most metabolisms of the body. To investigate the immuno-enhancing effects of biophoton energy projector (BEP) producing light energy, pigs were irradiated with BEP for 8 weeks. Swine peripheral blood mononuclear cells (sPBMCs) were isolated from the blood of irradiated pigs. In this study, the antigen uptake and mitochondrial membrane potential of sPBMCs were measured by flow cytometric analysis. The irradiation of BEP increased the antigen uptake of sPBMCs. For functional analysis, the production of Bordetella bronchiseptica-specific IgG, measured using antigen-specific ELISA, was increased during the period of BEP irradiation. Taken together, the results suggest that the irradiation of BEP has immune-enhancing effects on sPBMCs.

The present study investigated the blood flow at microvascular network. The role of the blood viscosity and the yield stress of blood on the flow at the microvascular network was examined to find the condition of hemostasis. When the yield stress was less than 0.005Pa, there was no stagnant region in the capillary network used in the study. However, when the yield stress increased to 0.05Pa, stagnant areas began to appear, which grew and expanded rapidly with further increase in the yield stress. From the blood viscosity profile of a patient, one can estimate the yield stress of blood, from which the risk of hemostasis can be determined.

This research was planned and executed to evaluate how the composition of Yack-sun tea can affect the health conditions of people who are suffering from diet-related such as being overweight, are obese and have hyperlipidemia, by taking Yack-sun tea in a form of a nutritional supplement with our daily meals. We produced Kangjieum with Lycium chinense Mill., Polygonum multflorum Thunb, Cassia tora L., Crataegus pinnatifida Bge and Salvia miltiorrhiza Bge. Thus, we approach of oriental diet therapy area research of Kangjieum and analysis proximate composition, water soluble antioxidant content. The content(%, dry basis) of total carbohydrate was 60.23%, crude protein was 18.18%, crude ash was 11.36% and crude fat was 10.23% in Kangjieum. Total water soluble antioxidant content was 1.027 ㎍/㎖ of Kangjieum. We think that scientific and objective evaluation was done on the components of the Kangjieum prescription. This basic data could help guide the application of oriental medicinal resources into other foods and serve as a stepping-stone for use of Kangjieum in the burgeoning field of nutraceutical foods. Last, the scientific effects of oriental medicinal foods developed according to oriental medicinal theory. This theory is believed to be essential for government policy development concerning validation of medicinal effects and assessment, with the aim of fostering systematic development and providing guidance to food development in the interest of national health.

In this study, Artemisia capillaris, which has been used as oriental medicine area and folks remedy, was investigated for effective substance (scopoletin) analysis. As an attempt to develop new functional beverage by using medicinal herb, Artemisia capillaris. Therefore we investigate the effect of scopoletin in Artemisia capillaris on vessel and regional cerebral blood flow (rCBF) of rats. Artemisia capillaris extract was significantly decreased vessel constraction and significantly increased rCBF. Artemisia capillaris has often been cited in medical literature for its medicinal effects. Although the Korean Food and Drug Administration indicated Artemisia capillaris as the In-Jin-Sook which was allowed as a food stuff. From the view point of the subjects who eat In-Jin-Sook products, most of them ingested it for a certain pharmacological efficacy rather than as a beverage or a food. According to this facts, we need develop functional foods using In-Jin-Sook. Also scopoletin, get known to smooth muscle relaxation content was 326.13 ug/g. These results demonstrate that Artemisia capillaris has pharmaceutical effects and balanced nutritional contents. In according with Artemisia capillaris has a sufficiency of the terms use of food stuff in functional foods.

2010년의 북한의 연평도 피격 참사를 통하여 비상 대피에 대한 인식은 확산되고 있으나 재난 발생시 피난 및 대피시설에 대한 인식은 상대적으로 낮음 따라서, 이를 뒷받침할 수 있는 민방위 대피시설에 대한 전수조사를 통하여 문제점을 파악 분석하여 앞으로의 새로운 대피체계와 대피시설에 대한 기본적인 개념을 확립하고자 하였다. 본 조사를 통해 민방위 대피시설은 지역별로는 서울이 가장 많았고, 시설별로는 아파트주차장의 비중이 가장 높음. 1990～1999년에 건축된 지하1층 1,001～5,000㎡ 규모, 인접시설간 5분 이하의 거리에 주로 대피시설이 위치하고 있고 501인 이상의 인원을 수용할 수 있음. 대피시설 내부에 별도의 격실이 없는 시설이 많아 화생방 공격시 대피에 취약할 수 있고 방폭문도 없는 시설이 대부분이므로 폭탄이나 미사일 공격에 취약할 수 있음. 대피시설로 연결되는 출입구 개수도 대부분이 1개이므로 대피시 어려움이 예상됨이 파악되었다.

H대학 실습선 28명의 선원에 대하여 40일간 장기간 항해 전과 후의 혈액과 소변의 생화학적 분석을 실시하였다. 원앙 후 부원 및 모든 연령에서 요소질소와 요산수치(creatine 및 uric acid)가 증가된 것으로 보아 선상생활이 신장의 기능을 나쁘게 하거나 기능저하를 초래했다고 판단되어진다. 또 총콜레스테롤(TC)과 고밀도지단백콜레스테롤(HDL-C) 및 저밀도지단백콜레스테롤(LDL-C)은 원양 전보다 후에 유의하게 감소한 반면에 중성지방(TG)은 유의하게 상승하였다. 연령별로는 TC와 HDL-C가 30대, 40대에서 유의하게 감소하였고, TG는 30대가 유의하게 증가하였는데 특히 30대에서 몇몇 선원에 대해서는 원양 후 TG의 높은 증가를 보여 고지혈증이 의심되고 있다. 또한 소변검사에서도 간세포성기능 및 신장기능의 이상을 진단하는 담즙색소(UBG)와 요단백(PRO)에서 장기간 항해 전과 후 모두 양성반응이 나타난 선원이 각각 7명과 5명 이었다. 특히 우로빌리노겐(Urobilinogen : UBG)에서 양성반응이 크게 증가하여 한 달간 원앙을 통하여 간세포성기능이 저하되었거나 이상이 있음을 보여주고 있다.