This study was conducted to collect the patents of microbiome-based treatment technology for pets. An electronic search for microbiome or probiotics in brain nervous system disease was studied using the WINTELIPS database. Patent Cooperation Treaty of Korea, Japan, the EU, the US, and China that were registered by October 31, 2022 were selected in this study. A total of 206 patents were included for final analysis. Since 2016, patent activity has shown an explosive increase in recent years. China is the leading market in this technology field, and Korea has the second-highest market share. To provide the groundwork for the next research and development, we examined the industrial trend of microbiome for brain nervous system diseases in this study using an analysis of patents that have been applied for and registered up to this point. Looking at the overall patent trends by year in the technology field related to treating of brain and nervous system diseases using the microbiome, there was a tendency to repeat increasing and decreasing trends. However, considering 2021 and 2022, which have undisclosed sections, it can be seen that patent activity has tended to increase explosively in recent years, starting in 2016. If related studies use the patent analysis data constructed in this way strategically, it is expected that it will lead to patent registration and the development of new products, ultimately contributing to the revitalization of the companion animal industry.

This study analyzed the effect of workers' socio-psychological burden factors on musculoskeletal disorders. A survey was conducted targeting office and field workers in the Seoul metropolitan area. Analysis was performed using the results of 357 surveys out of 400 surveys. The analysis results were derived as follows. First, the socio-psychological burden factor did not show statistically significant results for musculoskeletal disorders. Second, it was found that job stress factors also had a positive effect on musculoskeletal disorders. Third, social psychological burden factors were found to be more positive than office workers than field workers. Fourth, there was a statistically significant correlation between job stress and musculoskeletal disease risk scores. From the above results, job stress factors affect musculoskeletal disease risk factors (work frequency, pain level, and duration) and the increase in musculoskeletal disorders and the number of accidents.

EBV-positive mucocutaneous ulcer (EBVMCU) is an indolent, superficial lymphoproliferative disorder that occurs in either iatrogenic or age-associated immunocompromised patients with latent Epstein-Barr virus (EBV) infection. Although EBVMCU is histologically similar with other lymphoproliferative disorders, such as EBV-positive diffuse large B cell lymphoma, the diseases are classified as distinct entities by the World Health Organization with different clinical manifestations, prognosis, and genetic profiles. EBVMCU commonly shows spontaneous regression by conservative management, reduction or cessation of immunosuppressive treatment, but local progression is possible. Complete remission of disease can be achieved with combination of surgical resection, chemotherapy and local radiation therapy. Herein, we report 2 cases of oral superficial lymphoproliferative disorders arising adjacent to the gnathic bone with striking differences in prognosis and bone involvement. One of the cases induced extensive osteomyelitis in the underlying bone. Furthermore, we discussed the differential diagnosis of EBVMCU and reviewed the former literature.

Background: The purpose of this study was to determine the bidirectional association between burning mouth syndrome (BMS) and depression disorders. Methods: A total of 854 pairs of BMS and 58 999 pairs of depression disorders matched 1:1 for age and sex were analyzed using conditional logistic regression models, which were adjusted for potential confounding factors. Results: Bidirectional analysis found that BMS was associated with depression disorders (odds ratio=4.64, P < 0.001) and depression disorders was also significantly associated with BMS (odds ratio=2.97, P < 0.001). Conclusion: These findings indicate a significant bidirectional association between BMS and depression disorders. The odds ratios suggest that BMS is a stronger predictor for incidence of depression disorders than depression disorders predicting incidence of BMS. Given this retrospective cohort design, the mechanisms underlying the association between BMS and depression disorders are not directly analyzed. Therefore, further investigation are needed to analyze the causality between BMS and depression disorders.

In order to conduct a study on the importance of the wrist joint, which causes a lot of pain among middle-aged people, in relation to work related to musculoskeletal disorders, the effect of stretching on grasping power was studied. In order to compare the grasping power of the wrist for middle-aged people in their 50s, the experiment was conducted by comparing before and after the wrist joint motion stretching. According to the experimental results of wrist gripping power for the control group and the experiment group on wrist gripping power, it was investigated that stretching did not change much in increasing wrist gripping power, but stretching application had an effect on wrist gripping power. In terms of preventing musculoskeletal accidents, reducing pain due to degenerative diseases, and preventing accidents, stretching seems to have an effect when approaching, so it is considered that continuous stretching before and after work is necessary. Therefore, it is suggested that stretching time secured quantitatively through safety and health education before work is necessary.

The development of graphene and graphene-like materials has been a breakthrough in the field of nanotechnology for its exceptional properties. It exhibits extraordinary properties owing to its unique, regular arrangement of carbon atoms in it. However, graphene is usually modified for specific applications, by introducing disorder in the system. Since disorders are ubiquitous during the synthesis of graphene and graphene-like materials, it is best to exploit the defects for tuning its exceptional properties for suitable device applications. Like in any material, the disorder can drastically affect the properties, and hence they are deliberately incorporated into the material. In this review, we discuss topics related to the creation and configuration of disorders in graphene such as corrugations, topological defects, vacancies, adatoms and sp3- defects. The effects of these disorders on the electrical, thermal, chemical and mechanical properties of graphene are analysed subsequently. Finally, we review earlier works on the modulation of structural defects in graphene for specific applications.

Extracellular vesicles (EVs) are nanovesicles that carry bioactive cargoes of proteins, lipids, mRNAs, and miRNAs between living cells. Their role in cellular communication has gained the attention of several research reports globally in the last decade. EVs are critically involved in sperm functions, oocyte functions, fertilization, embryonic development, and pregnancy. The review summarizes the state-of-theart of EVs research in the diagnostic and therapeutic (theranostic) potentials of the EVs during the pregnancy that might provide a solution for gestational disturbances such as implantation failure, maternal health problems, gestational diabetes, and preeclampsia. EVs can be found in all biological fluids of the fetus and the mother and would provide a non-invasive and excellent tool for diagnostic purposes. Moreover, we provide the current efforts in manufacturing and designing targeted therapeutics using synthetic and semi-synthetic nanovesicles mimicking the natural EVs for efficient drug delivery during pregnancy.

Purpose: This study aimed to develop a web-based video program related to abnormal mental disorder behaviors in standardized patients and verify its effectiveness for nursing students. Methods: This study consisted of pre-test and post-test for a non-equivalent control group design. The participants were 46 nursing students(experimental group: 23, control group: 23). The experimental group was trained in a video program that applied standardized patients, while the control group received traditional training. Data collected from March to June, 2020, were analyzed using IBM SPSS Statistics for Windows, version 25.0, chi-square test, Fisher's exact test, Mann-Whitney U test, and independent t-test. Results: The difference between the experimental and control groups was statistically significant in terms of learning satisfaction (Z=2.08, p=.038), learning self-efficacy(t=2.80, p=.009), motivation for transfer(t=3.45, p=.001), and clinical reasoning competence(t=2.28, p=.028). Conclusion: This study showed that a video program on abnormal mental disorder behaviors in standardized patients is an effective tool for mental health nursing education.

본 연구는 자폐 스펙트럼 장애 대상으로 동물매개중재의 국내 연구동향을 분석하여 향후 관련 분야의 연구방향을 제시하기 위한 것이다. 분석 선행연구는 2011년부터 2020년 까지 총 6편을 최종 선정하여 출판 수, 연구 대상자 연령, 프로그램 회기, 종속 변인으로 분석하고 결과를 제시하였다. 분석결과는 2020년도에 출판 수가 가장 많았으며 대상자 연령은 유아ㆍ아동기가 가장 많았다. 또한 프로그램 회기는 10회기 이상 20회기 미만 회기들이 주를 이루었고 17회기가 가장 많았다. 종속 변인으로는 사회적 상호작용이 가장 많이 활용이 된 것으로 볼 수 있었다. 동물매개중재는 사회성이 부족한 자폐 스펙트럼 장애 대상에게 사회적 상호작용에 긍정적 효과를 주었다는 것을 증명해주었으며 동물매개 중재 프로그램이 자폐 스펙트럼 장애 대상으로 다양한 연령층과 다양한 변인들로 연구를 할 수 있게끔 향후 방향성을 제시하였다는 데 의의가 있다.

Ammonium (NH4 +-N) and nitrate-nitrogen (NO3-N) fertilizers were spread 30 kg/10a and 60 kg/10a, respectively, as additional fertilizers in nitrogen fertilization to investigate their effects on spring kimchi cabbage's physiological disorders during cold storage. The initial weight of spring kimchi cabbage after harvesting was 3.80 kg with two-fold NO3-N, whereas it was 3.22 kg with one-fold NO3-N. After 90 days of cold storage, the total loss ratio became lower as the nitrogen fertilizer ratio increased. The pH increased, reducing sugar content decrease during the storage. Black speck occurrence became higher as the nitrogen fertilizer increased. Mid-rib brown stain and soft rot were observed slightly in kimchi cabbage regardless of the nitrogen fertilizer ratio. Two-fold NO3-N fertilization showed a positive effect on increasing weight and reducing kimchi cabbage loss, but it exhibited a negative effect on the black speck. The method and content of nitrogen fertilization of spring kimchi cabbage may be adjusted according to the usage and storage periods.

Objective: The Modified Barthel Index (MBI) measures individuals’ level of independence in performing activities of daily living. The purpose of this study was to examine the internal consistency and construct validity of the MBI for children with rare disorders. Methods: The study participants are children with rare disorders who have muscle weakness including Barth syndrome and congenital muscular dystrophy (N = 113). The MBI was completed by participants in either an online format utilizing the UF Qualtrics system or a pencil-and-paper format. Statistical analysis was conducted to examine the psychometric properties of the MBI. Results: The MBI showed excellent internal consistency for children with Barth syndrome (Cronbach’s α = .91) and congenital muscular dystrophy (Cronbach’s α = .93). Construct validity was supported by a significant difference in MBI scores among participants grouped by diagnoses. MBI score was significantly different between the unaffected group and congenital muscular dystrophy (p < .0001) as well as between the unaffected group and Barth syndrome (p < .0001). Conclusion: The psychometric properties of the MBI present good reliability and construct validity suggesting suitability for use as an outcome measure for children with rare disorders.

목적 : 본 연구는 정신장애인을 대상으로 작업치료 영역에서 직업재활에 대해 알아보기 위해 진단군 및 중재의 유형과 효과에 대하여 국외 연구들을 중심으로 체계적 고찰을 실시하고자 한다. 연구방법 : 2010~2019년까지 자료 검색을 위해 PubMed, EMBASE, OTseeker 둥 총 12개의 데이터베 이스에서 Mental disorder, Mental illness, Psychiatric disorder, Psychotic disorders, Bipolar disorder, Depressive disorder, Schizophrenia, Schizoaffective disorder, Employment, Job, Work, Vocational, Occupational therapy를 검색하였다. 최종 분석에 포함된 연구는 총 29편이었다. 결과 : 연구에 포함된 진단군은 조현병이 가장 많았다. 직업재활을 중재 유형별로 살펴보면 지원고용이 16 편로 가장 많았고, 사회기술 및 인지재활 훈련+지원고용 10편, 사회기술 및 인지재활 훈련, 기타 직업적 접근법, 사회기술 및 인지재활 훈련+기타 직업적 접근법은 각각 1편이었다. 고용 유형에 따른 중재 유형별 고용률에서 효과를 나타낸 연구를 살펴보면, 경쟁고용에서는 지원고용이 13편, 비경쟁 고용에서는 기타 직업적 접근법이 1편, 유급고용에서는 지원고용이 3편으로 각각 가장 많았다. 결론 : 추후 국내 정신장애인을 대상으로 체계적이고 종합적인 직업재활서비스를 제공하기 위한 기초자료와 정책과 평가체계 도입의 근거로 활용할 수 있을 것이다.

The study evaluated the accuracy and intra-rater reliability for OWAS (Ovako Working posture Analysing System), RULA (Rapid Upper Limb Assessment), REBA (Rapid Entire Body Assessment) to improve their evaluation accuracy and reliability. Participants (n = 163) with undergraduate degree were recruited in this study and trained for 6 hours about the ergonomic assessment methods. Ergonomic assessments were conducted using OWAS, RULA, and REBA for a representative work with dynamic posture found in manufacturing industries. The study compared action categories (overall level) and detailed evaluation scores for individual body part. Action categories of the participants significantly differed from the golden reference defined by ergonomic experts. The participants underrated or omitted scores for truck (37.4% of the participants) and legs (52.8%) in OWAS. Similarly, the participants underrated or omitted additional scores for all body parts except the hand and wrist in RULA (53.5%) and REBA (54.8%). On the other hand, the participants overrated scores for the hand and wrist in RULA (55.2%) and REBA (39.9%). The results found in this study can help of selecting focus points and parts during assessment and education to improve accuracy and reliability of the ergonomic assessment methods.

Background: There is an opinion that improper postures of the head and cervical spine are associated with temporomandibular joint (TMJ) disorders (TMDs). Objects: The aim of this study was to investigate the proportions among the cervical kyphotic angle, physical symptoms including the pain intensity level of the TMJ, and severity of TMD disability in patients diagnosed with TMD. Methods: Sixty-two subjects participated in the study. The evaluation tools included measurements of the cervical kyphotic angle based on the Ishihara index, pressure pain threshold (PPT) on the TMJ, maximal mouth opening (MMO) without pain, current pain intensity level of the TMJ measured using the Quadruple Visual Analogue Scale (QVAS), Korean TMD (KTMD) disability index, KTMD Symptom Frequency/Intensity Scales (SFS/SIS), and Korean Headache Impact Test-6. Correlation analysis was conducted to investigate the correlations between the cervical kyphotic angle and parameters related to TMJ symptoms. Results: Variables that were significantly correlated with the cervical kyphotic angle were the PPT around the TMJ (r = 0.259, p < 0.05), current pain intensity level of the TMJ based on the QVAS (r = –0.601, p< 0.01), and usual pain intensity level based on the SIS (r = –0.379, p < 0.01). The level of TMD functional disability was significantly correlated with the degree of headache (r = 0.551, p < 0.01), level of PPT of the TMJ (r = –0.383, p < 0.01), pain-free MMO (r = –0.515, p < 0.01), pain intensity level of the TMJ based on the QVAS (r = 0.393, p < 0.01), TMD symptom frequency (r = 0.739, p < 0.01), usual pain intensity of the TMJ (r = 0.624, p < 0.01), and most severe pain intensity of the TMJ (r = 0.757, p < 0.01). Conclusion: There is a positive correlation between the cervical kyphotic angle and PPT and a negative correlation between the current and usual pain intensity levels of the TMJ. The cervical kyphotic angle was a predictor of the pain level, tenderness threshold, and intensity of pain in the TMJ.

분노는 알코올 사용 장애자들이 재발하기 전에 가장 흔하게 경험하는 정서 중 하나이다. 본 연구는 알코올 사용 장애자의 분노 경험에 따른 자율신경계 반응 특성을 규명하고자 하였다. 본 연구에는 알코올 사용 장애로 진단받고 치료 중인 남성 환자 12명과 이들과 연령 및 학력수준이 유사한 일반인 남성 14명이 참여하였다. 분노를 유발하기 위하여 시청각 동영상을 제시하고, 이때 나타난 심리 및 자율신경계 반응(피부전기 활동)을 측정하였다. 연구 결과, 참여자들이 경험한 정서의 강도에서는 알코올 집단과 일반인 집단에서 차이가 나타나지 않았다. 반면, 알코올 집단은 안정 상태에 비해 분노 상태에서 비중독자에 비해 피부전도 수준, 피부전도 반응 그리고 피부전도반응 수가 유의하게 낮았다. 이 결과는 알코올 중독자들이 분노를 처리하는 동안에 생리 반응에서 이상이 나타남을 시사하였다. 알코올 사용 장애자들의 분노 경험 동안에 나타난 생리 반응 이상을 완화할 수 있는 개입방법을 개발한다면 알코올 사용 장애자들의 정서 처리 문제를 해결할 수 있어 그들의 재발 방지에 도움을 줄 수 있을 것이다.

This study was conducted to compare the effect of salicylic acid (SA), an ethylene biosynthesis inhibitor, and the 1-methylcyclopropene (1-MCP) fumigation, to prevent fruit quality deterioration and physiological disorders during the shelf-life of Korea’s leading export grape variety ‘Campbell Early’. The berries treated with SA after 1- MCP fumigation (1-MCP+SA) showed a higher firmness value and titratable acidity than single treatment of SA or 1-MCP. The rate of shattered berry was high as 41.7% for 100ppm ethephon spray, 40.8% for 25μM SA, and 38.2% for 1,000ppb 1-MCP, but showing only 18.7% when the SA was applied after 1-MCP fumigation. The ratio of short brushes less than 1mm was largest at 74.3% for ethephon treatment, while 1-MCP+SA treatment was found to have the longest brush length among all treatments, with a 2-4mm ratio of 22.8% and a 4-6mm ratio of 27.9%. The weight of rachis was found to be the lowest at 2.3g in the ethephon treatment, and the reduction of rachis weight loss per cluster by 1-MCP+SA treatment was evident. In addition, 1-MCP+SA treatment were effective in mitigating stem browning and berry decay during the 16-day storage period at 19oC in this cultivar, so it is believed that they can be used as a practical post-harvest treatment in grape exportation.

Background: Temporomandibular disorder (TMD) is characterized by pain and limited range of motion in the jaw. TMD patients generally prefer to chew on the unaffected or less-affected side, and this tendency often results in asymmetries in masseter muscle thickness and range of mandibular motion. Objects: The purpose of this study was to compare the asymmetries in masseter muscle thickness and range of mandibular motion in subjects with and without temporomandibular disorders. Methods: Thirty-nine subjects were divided into two groups: A TMD group (n1=19) and a control group (n2=20). The jaw opening range and laterotrusion were measured using a digital vernier caliper. The masseter muscle thickness was examined in both the resting state and the maximal clenching state using ultrasonography. The absolute asymmetry indices calculated based on the laterotrusion and masseter muscle thickness of the respective right and left sides. A two-way ANOVA and a Mann-Whitney U test were used for statistical analysis. Results: No significant different was found in the masseter muscle thickness between the TMD and control group. A significant difference was found in the absolute asymmetry indices of mandibular laterotrusion between the TMD and control groups (p<.05). Furthermore, the ranges of jaw opening were significantly different between males and females (p<.05). The absolute asymmetry index values of masseter muscle thickness at rest and during maximal clenching were also significantly different between males and females (p<.05). Conclusion: These results demonstrated that the subjects with TMD had a larger degree of asymmetry in laterotrusion than those without TMD. Therefore, a physiotherapy program needs to be designed to restore normal laterotrusion capacities for TMD subjects. These results also showed that female subjects had greater absolute asymmetry indices in masseter muscle thickness than male subjects. Therefore, more training is needed to promote bilaterally balanced chewing among women.

본 연구의 목적은 온도와 토양수분에 따른 마늘의 생육, 생리장해 및 수량에 미치는 영향을 구명하고자 실시 하였다. 실험은 온도가 6℃ 차이가 나는 온실에서 수행 되었는데, 정식부터 수확까지 외기(A)보다 3℃(A+3℃), 6℃(A+6℃) 고온조건, 토양수분은 적습(OI) 대비 수확기 무렵의 다습(EI) 처리를 하였다. 그 결과, 마늘 생육특성은 온도와 토양수분 조건(0.34m3/m3)에 따라 고도의 유의성을 보여 고온일수록 그리고 적습 처리구일수록 컸다. 초장은 외기보다 A+6℃-OI 처리구에서 47.4cm로 가장 컸으며, 엽장과 엽폭 역시 외기보다 A+6℃-OI 처리구가 각각 16.1cm, 2.4cm로 가장 컸다. 마늘재배 기간 중 외기보다 3℃, 6℃ 고온조건이 되면 스펀지마늘 발생율이 높아져 A+6℃-OI 처리구는 12.9% 발생하였고, A-EI 처리구에서는 전혀 발생하지 않았으며, 인편무게와 1쪽당 무게는 A+6℃ 고온구에서 크게 감소하여 수량이 외기 대비 A+6℃ 처리구는 평균 51%, A+3℃ 처리구는 평균 22% 감소하였다. 따라서, 마늘재배시 외기보다 6℃ 고온조건과 다습조건이 되면 상품수량 감소하고, 생리장해 발생이 많아지는 것으로 나타났다.