Background: A functional movement screen (FMS) can be used as an intervention method as well as a test method. Compensatory action due to a faulty functional movement result in imbalance of the body, and decrease in proprioceptive sensation and flexibility. However, the benefits of exercise using FMS on proprioceptive sensation and flexibility are unclear. Objectives: This study aimed to investigate the effect of exercise using FMS on the proprioceptive sensation and flexibility. Design: Pretest-posttest control group experimental design. Methods: Fifty-two young adults in their 20s were divided into an FMS exercise group (FEG, n=26) and a control group (CG, n=26). The FEG conducted FMS exercise intervention for 12 days, and CG did not implement any intervention. Each group evaluated proprioceptive sensation and flexibility before and after exercise. To measure proprioceptive sensation, the angles were measured at both shoulder joints, elbow joints, hip joints, and knee joints using the active joint sensory position test method. To measure flexibility, situp forward bending evaluation was performed. Results: In the FEG, bilateral proprioceptive sensation and flexibility improved significantly after intervention (all P<.01). There were no significant differences in the CG (all P>.05). After the intervention, there were significant differences between the groups in both proprioceptive sensation and flexibility (all P<.05). Conclusion: The findings suggest that exercise using FMS can significantly improve proprioceptive sensation and flexibility. Therefore, it is suggested to consider exercise using FMS as an intervention to increase joint proprioceptive sensation and flexibility.

The physical and antibacterial properties of ophthalmic lenses fabricated by copolymerization with hydrogel monomers using two types of graphene were measured, and their usability as contact lens materials was analyzed. For polymerization, silicone monomers, including SID-OH, 3-(methacryloxy)propyl tris(trimethylsiloxy)silane, and decamethylcyclopentasiloxane, were used, and N,N-dimethylacetamide, ethylene glycol dimethacrylate as a crosslinking agent, and azobisisobutyronitrile as an initiator were added. Also, graphene oxide nanoparticle (GON) and graphene nanoplate (GNP) were used as an additive, and the physical properties of the lenses fabricated after copolymerization were evaluated. The fabricated lenses satisfied the basic physical properties of general hydrogel contact lenses and showed the characteristics of lenses with high water content, and the disadvantage of very weak durability, due to low tensile strength. However, it was confirmed that the tensile strength and antibacterial properties were greatly improved by adding GON and GNP. With GON, the oxygen permeability and refractive index of the fabricated lenses were slightly improved. Therefore, it was determined that the graphene materials used in this study can be used in various ways as a contact lens material.

Social interactions often involve encountering inconsistent information about social others. We conducted a functional magnetic resonance imaging (fMRI) study to comprehensively investigate voxel-wise temporal dynamics showing how impressions are anchored and/or adjusted in response to inconsistent social information. The participants performed a social impression task inside an fMRI scanner in which they were shown a male face, together with a series of four adjectives that described the depicted person's personality traits, successively presented beneath the image of the face. Participants were asked to rate their impressions of the person at the end of each trial on a scale of 1 to 8 (where 1 is most negative and 8 is most positive). We established two hypothetical models that represented two temporal patterns of voxel activity: Model 1 featured decreasing patterns of activity towards the end of each trial, anchoring impressions to initially presented information, and Model 2 showed increasing patterns of activity toward the end of each trial, where impressions were being adjusted using new and inconsistent information. Our data-driven model fitting analyses showed that the temporal activity patterns of voxels within the ventral anterior cingulate cortex, medial orbitofrontal cortex, posterior cingulate cortex, amygdala, and fusiform gyrus fit Model 1 (i.e., they were more involved in anchoring first impressions) better than they did Model 2 (i.e., showing impression adjustment). Conversely, voxel-wise neural activity within dorsal ACC and lateral OFC fit Model 2 better than it did Model 1, as it was more likely to be involved in processing new, inconsistent information and adjusting impressions in response. Our novel approach to model fitting analysis replicated previous impression-related neuroscientific findings, furthering the understanding of neural and temporal dynamics of impression processing, particularly with reference to functionally segmenting each region of interest based on relative involvement in impression anchoring as opposed to adjustment.

Emotional labor, characterized by a dysfunctional type of emotional regulation called surface acting, has detrimental psychological consequences on employees, including depression and social anxiety. Because such disorders exhibit psychological characteristics manifested through brain activation, previous studies have succeeded in distinguishing individuals with depression and social anxiety from healthy controls using their functional connectivity characteristics. However, it has not been established whether the functional connectivity characteristics associated with emotional labor are distinguishable. Thus, we obtained resting-state fMRI data from participants in the emotion labor (EL) group and control (CTRL) group, and we subjected their whole-brain functional connectivity matrices to a linear support vector machine classifier. Our analysis revealed that the EL and CTRL groups could be successfully distinguished on the basis of individuals' connectivity patterns, and confidence in the classification was correlated with the scores on the depression and social anxiety scales. These results are expected to provide insight on the neurobiological characteristics of emotional labor and enable the sorting of employees undergoing adverse emotional labor utilizing neurobiological observations.

Barnea manilensis is a bivalve which bores soft rocks, such as, limestone or mudstone in the low intertidal zone. They make burrows which have narrow entrances and wide interiors and live in these burrows for a lifetime. In this study, the morphology and the microstructure of the valve of rock-boring clam B. manilensis were observed using a stereoscopic microscope and FE-SEM, respectively. The chemical composition of specific part of the valve was assessed by energy dispersive X-ray spectroscopy (EDS) analysis. 3D modeling and structural dynamic analysis were used to simulate the boring behavior of B. manilensis. Microscopy results showed that the valve was asymmetric with plow-like spikes which were located on the anterior surface of the valve and were distributed in a specific direction. The anterior parts of the valve were thicker than the posterior parts. EDS results indicated that the valve mainly consisted of calcium carbonate, while metal elements, such as, Al, Si, Mn, Fe, and Mg were detected on the outer surface of the anterior spikes. It was assumed that the metal elements increased the strength of the valve, thus helping the B. manilensis to bore sediment. The simulation showed that spikes located on the anterior part of the valve received a load at all angles. It was suggested that the anterior part of the shell received the load while drilling rocks. The boring mechanism using the amorphous valve of B. manilensis is expected to be used as basic data to devise an efficient drilling mechanism.

Periodontitis, especially in its chronic form, is one of the leading causes of tooth loss, significantly affecting the quality of life in the modern era of aging society. Recent studies have revealed a potential correlation between periodontitis and various systemic diseases, including cardiovascular diseases and Alzheimer’s dementia (AD). With the body of epidemiologic evidence that links these separate disease entities, several lines of hypotheses have been postulated to provide mechanistic understandings that mostly comprises abnormal regulation of immunologic and inflammatory signaling. In this review, we revisit the experimental findings that describe virulence factors derived from Porphyromonas gingivalis, including gingipains and lipopolysaccharides, as well as their roles in the pathophysiology of AD. In addition, we address potential immunologic challenges imposed by this bacterial pathogen contributing to progression of AD.

정신요양시설은 정신보건법, 정신건강증진 및 정신질환자 복지서비스 지원에 관한 법률의 제정과 개 정의 과정에서 사회복지기능보다는 의료적 기능으로 인식되었다. 정부의 지역사회중심의 커뮤니티케어 정책 발표는 정신요양시설의 존재적 위기감을 가져왔고, 거주이용인의 요양과 사회복귀 목적의 서비스 를 제공하는 정신요양시설은 발전적 미래를 위하여 새로운 방향을 제시하여 할 필요성이 제기되었다. 정신요양시설 미래의 방향성을 설정하기 위해 기존의 문헌과 자료를 탐색하여 정신요양시설의 일반 적 현황과 거주이용인의 특성 변화에 따라 제공된 현재의 정신요양시설 서비스가 거주이용인의 이용만 족, 거주이용인 회복의 성과에 영향을 미쳤는지 살펴보았다. 연구결과 거주이용인의 회복지향을 위한 정신요양시설의 정체성 확립과 기능전환의 방향은 다음과 같다. 첫째 거주이용인의 특성을 반영한 지역사회 거주환경으로 인식제고, 둘째 지원주택의 특성을 적용 한 거주지원시설로 변화 지향, 셋째 사회복지성격의 지원서비스의 명시로 차별성과 정체성 확립, 넷째 거주이용인 회복지향 서비스의 충분한 제공이다. 연구의 한계점으로 나타난 정신요양시설의 물리적 환경, 중점 서비스 방향, 지역사회의 특성이 정신요 양시설 운영에 미치는 영향정도와 정신요양시설과 정신재활시설이 차별성과 통합여부에 대한 연구가 필 요하다.

In existing ceramic mold manufacturing processes, inorganic binder systems (Si-Na, two-component system) are applied to ensure the effective firing strength of the ceramic mold and core. These inorganic binder systems makes it possible to manufacture a ceramic mold and core with high dimensional stability and effective strength. However, as in general sand casting processes, when molten metal is injected at room temperature, there is a limit to the production of thin or complex castings due to reduced fluidity caused by the rapid cooling of the molten metal. In addition, because sodium silicate generated through the vitrification reaction of the inorganic binder is converted into a liquid phase at a temperature of 1,000 °C. or higher, it is somewhat difficult to manufacture parts through high-temperature casting. Therefore, in this study, a high-strength ceramic mold and core test piece with effective strength at high temperature was produced by applying a Si-Na-Ti three-component inorganic binder. The starting particles were coated with binary and ternary inorganic binders and mixed with an organic binder to prepare a molded body, and then heat-treated at 1,000/1,350/1,500 °C to prepare a fired body. In the sample where the two-component inorganic binder was applied, the glass was liquefied at a temperature of 1,000 °C or higher, and the strength decreased. However, the firing strength of the ceramic mold sample containing the three-component inorganic binder was improved, and it was confirmed that it was possible to manufacture a ceramic mold and core via high temperature casting.

In this paper analyzed the features of how native Korean speakers (K) and native Vietnamese Korean learners (VKL) organize the Apology conversation, focusing on the functional phase. Based on the discourse analysis, a role play was conducted to collect data. In order to investigate the influence of social variables (social status, intimacy), learners' mother tongues and learners' Korean proficiency, different social variables were given in role-play situations, and learners' Korean proficiency was limited to intermediate and advanced levels. The results of analyzing conversations focusing on ‘Error Checking–Apology-Apology Acceptance’, which is the intermediate phase of Apology conversation, are as follows. First, in the Error Checking Phase, K tended to make indirect or preliminary remarks. In contrast, VKL immediately presented communication purposes, and advanced VKL tended to use indirect speech and additional statement. Second, in the Apology phase, the higher social status the other party has and the lower intimacy the two speakers has, the more passive K were. Interestingly, VKL showed the same pattern. For intermediate-level VKL, it was observed that the dialogue sequences were not completed. Third, in the Apology Acceptance phase, K repeatedly expressed apologies through complex dialogue sequences. However, VKL performed a concise conversation by simple dialogue sequences, and the intermediate-level VKL expressed ‘relief’ and ‘gratitude’.

Flammulina velutipes, known as winter mushroom in the family of Physalacriaceae, is the main edible and export mushroom with the third highest production after oyster and king oyster mushroom in Korea. However, as normal consumers regard F. velutipes as a simple subsidiary material, there is a limitation to increasing mushroom demand. In order to overcome the consumption limit and increase the differentiation of new varieties, it is necessary to breed varieties with enhanced functionality in consideration of consumer preferences. Therefore, the study was performed to analyze nutrient components and several useful functional substances with 26 genetic resources of F. velutipes. Analyses of inorganic compound(Ca, K, Mg) and 15 amino acids revealed that Strain 4148 had the highest content among the 26 strains. Beta-glucan, which increases immune activity and polyphenol, which exert antioxidant effects were higher in non-white strains than in white strains with a small number of exceptions. Among the five fatty acids, linoleic acid(an omega-6 fatty acid) and α-linolenic acid(an omega-3 fatty acid), were detected in six mushroom strains. α-linolenic acid, which was not found in five major mushrooms including oyster mushrooms, was identified in F. velutipes. The results of HPLC analysis showed that ‘Auram’ (Strain 4232) and ‘Baekseung’(Strain 4230) had the highest content of the stabilizing neurotransmitter GABA(15.38 μg/ml and 20.56 μg/ml, respectively) among non-white and white strains, respectively. Our findings provide useful information for breeding F. velutipes to obtain strains with enhanced functionality.

Corni Fructus (CF) is a fruit of Cornus officinalis Sieb. et Zucc. and has been used as traditional oriental medicine. It has various functional qualities such as being antioxidative, anti-inflammatory, antidiabetic, antihyperglycemic, and immunity-regulating. In the current study, CF was extracted from two conventional extract solvents (distilled water (DW) and 70% ethanol) with/without high-speed homogenization (HSH) treatments. The extract was characterized by measuring the total polyphenol contents and antioxidant activities. The HSH treatment significantly improved the total polyphenol content (from 28.4±0.9 mg/mL to 35.5±0.9 mg/mL), ABTS (from 59.8±0.4% to 78.4±2.7%), and DPPH radical scavenging activities (from 50.8±1.4% to 59.7±2.8%) of the DW extract and showed a level similar to that of 70% ethanol extract. The CF extracts were further used to prepare functional jelly with gelatin and other components such as pectin, fructooligosaccharide, and citric acid. The jelly’s hardness, springiness, gumminess, and cohesiveness were characterized using a texture profile analysis (TPA).

The endothelium, a continuous monolayer of cells that surrounds blood vessels, has a variety of physiological roles. Chronic exposure to psychological and physical stress, oxidative stress, and inflammation activates the endothelial signaling cascade, resulting in vascular dysfunction such as vasospasm, thrombosis, and abnormal vascular proliferation. Aging is also a significant factor in vascular dysfunction, mainly developing structural and functional changes in the endothelium. The molecules involved in endothelial dysfunction are typically angiopoietin-1 (Ang-1), Tie2, and tight junction proteins. Ang-1, an oligomeric-secreted glycoprotein, is required for the correct organization and maturation of newly-formed vessels. Ang-1 binding to tyrosine kinase receptors Tie-2 leads to the phosphorylation and activation of multiple signaling pathways related to vascular permeability. Endothelial junctions are another vital target of Tie-2 activation. Nutrition and food are closely connected with vascular dysfunction and permeability. The caloric restriction prevents age-related declines in endothelial function. Dietary patterns that prioritize moderate intake of fruits and vegetables, whole grains, low-fat dairy products, and lean meats improve endothelial function in the elderly. Natural products such as Centella asiatica, Pueraria montana, and Piper retrofractum have also been shown to help inhibit endothelial dysfunction. This review provides an update on aging-related vascular dysfunction and the role of food and nutrition.