바이러스 여과는 동물세포기반 바이오 의약품 제조에서 중요한 정제 공정으로, 특수하게 설계 및 제조된 분리막 을 사용하여 바이러스를 차단하고 항체 등 바이오 의약 물질을 선택적으로 통과시킨다. 바이러스 필터의 핵심 성능인 바이러 스 제거율과 항체 및 단백질의 회수율은 필터의 기공 구조와 대칭성뿐만 아니라, 여과 조건(표면 다공성, 압력, 유속, pH, 이 온 강도 등)에 따라 달라진다. 특히 단백질 오염은 비가역적 및 가역적 오염으로 구분되며, 추가로 blocking 모델을 통해 정밀 하게 분석하였다. 본 총설에서는 바이러스 필터 및 여과 공정의 이해 및 최적화를 위해 필터 구조, 제거 기작과 막오염 현상 을 소개하고, 바이러스 여과 공정에서 제거성능에 영향을 미치는 다양한 인자를 분석해보고자 한다.

This study examines the development of the Association of Southeast Asian Nations (ASEAN)’s Self-Certification of Origin mechanism through two key phases. From 1993 to 2015, ASEAN strove to establish a common market and deepen economic integration. During this period, it introduced various pilot projects to enhance trade, streamline certification procedures, and experiment with trade facilitation initiatives. Following the official establishment of the ASEAN Economic Community in 2015, the focus shifted towards harmonizing trade procedures, enhancing regional coordination, and standardizing customs processes. These efforts culminated in the launch of the ASEANwide Self-Certification (AWSC) in 2020. In Vietnam, however, the implementation of AWSC has faced significant challenges. Despite these obstacles, the country has taken proactive steps to integrate AWSC into its trade system by issuing domestic regulations and guidance from regulatory authorities. This study explores the specific difficulties Vietnam faces in implementing AWSC and proposes recommendations to enhance its effectiveness.

As an emerging force in the entertainment field of the new media era, the rise and development of Chinese mini web dramas are the result of the interweaving of multiple factors, with profound social, cultural and technological changes underlying them. They provide the public with a self-isolated heterotopia that breaks away from the "heavy reality", featuring high plot density and excitement. Against this backdrop, this paper approaches from the perspective of psychoanalysis, takes Lacan's "pleasure" theory as the theoretical framework, divides the development process of mini web dramas into three stages: the initial trial stage, the middle-term exploration stage and the current quality improvement stage, analyzes the consumption practice of mini web dramas under the "pleasure" theory, and further dissects the phenomena of racing production under the "fast-food mode" and consumption alienation under the generalization of commodity logic in the mini web drama industry, so as to provide theoretical support and practical inspiration for the innovative development of the mini web drama industry.

대한민국의 도로망 확장과 복잡화에 따라 터널의 수와 연장이 지속적으로 증가하고 있다. 이와 함께 시멘트콘크리트 포장의 성능과 수명에 미치는 환경 조건의 중요성도 높아지고 있다. 특히, 많은 고속도로 구간이 시멘트콘크리트로 시공되었으며, 기존 연구는 온습 도 차이에 따른 슬래브의 부등건조수축 현상을 주로 다루었다. 슬래브 상하부의 온습도 차이는 일일 및 계절적 주기에 따라 컬링과 와핑을 유발하며, 이러한 현상은 포장의 평탄성과 주행성에 문제를 일으킨다. 그러나, 콘크리트 내부 습도 변화와 이에 따른 장기적인 변형 거동에 대한 연구, 특히 배수가 어려운 터널 환경에서 습도 변화가 콘크리트 슬래브의 변형에 미치는 영향에 대한 이해는 미비 한 실정이다. 본 연구는 이러한 문제를 해결하기 위해 터널과 같은 환경에서 하부 습도 조건이 콘크리트 슬래브의 거동에 미치는 영향을 실험적으 로 조사하고자 한다. 실험에서는 서로 다른 하부 수침 조건을 적용하여 콘크리트 시편을 제작하고, 부등건조수축으로 인한 변형률과 수직변위를 측정하였다. 이를 통해 슬래브의 습도 분포와 변형 거동 간의 관계를 파악하고, 장기적인 성능 예측에 필요한 데이터를 확 보할 예정이다. 또한, 유한 요소 해석(FEM)과 데이터 간의 관계 분석을 통해 실험 결과의 신뢰성을 높이고, 향후 터널 포장 설계에 반 영할 수 있는 구체적인 지침을 마련할 것이다.

Volatile organic compounds (VOCs) are commonly produced in the combustion of fossil fuels and in chemical industries such as detergents and paints. VOCs in atmosphere cause different degrees of harm to human bodies and environments. Adsorption has become one of the most concerned methods to remove VOCs in atmosphere due to its high efficiency, simple operation and low energy consumption. Biomass-based porous carbon (BPC) has been considered as the most promising adsorption material because of the low cost and high absorption rate. In this paper, the key characteristic (e.g., specific surface area, pore structure, surface functional groups and basic composition) of BPC affecting the adsorption of VOCs in atmosphere were analyzed. The improvement of adsorption capacity of BPC by common modification methods, such as surface oxidation, surface reduction, surface loading and other modification methods, were discussed. Examples of BPC adsorption on different types of VOCs including aldehydes, ketones, aromatic VOCs, and halogenated hydrocarbons, were also reviewed. The specific adsorption mechanism was discussed. Finally, some unsolved problems and future research directions about BPC for adsorbing VOCs were propounded. This review can serve as a valuable reference for future developing effective biomass-based porous carbon VOCs adsorption technology.

Periodontal disease (PD) is strongly linked to increased risk of oral squamous cell carcinoma (OSCC); however, the specific mechanism through which the development of PD and OSCC is simultaneously promoted remains unclear. This study explored the impact of periodontal pathogens on OSCC progression and the contribution of periodontal pathogen-stimulated OSCC to PD development. The expression of osteoclastogenesis-inducing factors was assessed using quantitative reverse transcription polymerase chain reaction analysis following stimulation of OSCC with lipopolysaccharide (LPS) derived from the periodontal pathogen Porphyromonas gingivalis (Pg), a pathogen commonly responsible for PD. The cell counting kit-8 assay was used to determine the effects of Pg-LPS on OSCC proliferation and drug resistance to cisplatin and 5-fluorouracil. The effects of conditioned medium (CM) derived from Pg-LPS–stimulated OSCC on osteoclastogenesis was evaluated using tartrate-resistant acid phosphatase (TRAP) staining on bone marrow-derived macrophages (BMMs). Pg-LPS administration in SCC-25 and YD-8 OSCC cell lines induced a significant increase in receptor activator of nuclear factor kappa-B ligand mRNA expression; however, it did not affect cell proliferation. Treatment with CM derived from Pg-LPS–stimulated SCC-25 or YD-8 cells markedly enhanced the formation of TRAP-positive multinucleated cells during osteoclast differentiation of BMMs. Altogether, these findings demonstrate that Pg-LPS–stimulated OSCC promoted osteoclastogenesis through a paracrine mechanism.

점박이응애(Tetranychus urticae)는 250과 1400여종의 식물에 피해를 주고 있는 해충으로 높은 번식력, 근친 교배, 무성생식, 짧은 수명주기 로 년간 발생회수가 많기 때문에 약제에 대한 저항성이 빠르게 발달하는 종이다. 저항성 기작은 AChE 저해, sodium channel modulator, glutamate gated chloride channels allosteric, mite growth inhibitors, inhibitors of acetyl CoA carboxylase, mitochondrial ATP synthase 저 해, mitochondrial complex I, II, III, 그리고 electron transport 저해 등이 있으며 약제에 따라 작용기작이 다르므로 약제살포 시 확인이 필요하 다. 약제저항성 발달을 평가하는 독성시험방법으로 slide dip, leaf dip, leaf disc, topical application, vial leaf dip, spray potter tower, leaf vial dipping 등이 있으며 최근에는 분자학적 진단법 등도 개발되어 있으나 이들 방법은 해충 종이나 발육상태에 약제에 따라 정확도가 달라지므로 현장 에 가장 맞는 방법을 찾아야 할 것이다. 저항성 점박이응애를 효과적으로 관리하기 위한 방법으로 저항성 위험이 낮은 살응애제(chemical acaricide) 약제 선발, 천적인 칠레이리응애, 사막이리응애를 이용한 생물적 방제, 님, 제충국, 등 식물추출물이나 정유를 활용한 친환경적인 방법 등이 제시되 고 있으며 종합관리를 위한 다양한 요인을 찾아 약제 사용을 줄여 나가야 할 것이다.

In order to overcome the limitations of linear vibration energy harvesters and those using mechanical plucking, magnetic plucking vibration energy harvesters (MVEs) have garnered significant interest. This paper presents parametric studies aimed at proposing design guidelines for MVEs and compares two magnetic force models that describe interactions between two permanent magnets. A mathematical model describing the energy harvester is employed, followed by the introduction of two magnetic force models: an analytic model and an inverse square model. Subsequently, numerical simulations are conducted to investigate dynamic characteristics of MVEs, analyzing results in terms of tip displacement, voltage output, and harvested energy. Parametric studies vary the distance between magnets, the speed of the external magnet, and the beam shape. Results indicate that reducing the distance between magnets enhances energy harvesting effectiveness. An optimal velocity for the external magnet is observed, and studies on beam shape suggest greater energy harvesting when the shape favors deflection.

This study responds to literature calls to investigate the different social and psychological antecedents of negative consumer emotional well-being in the context of the health crisis Covid-19. We perform a path analysis on a sample of Australian consumers during the Covid-19 lockdown. We find that social norms and word-ofmouth increase consumer fear-of-missing-out which in turn fuels panic buying behavior. Such behavior is moreover spurred by positive motivations to panic buy. By contrast, we find that consumer ability to self-regulate during Covid-19’s reduces their tendencies to succumb to panic buying. We moreover find that such self-regulation is enhanced through sustainable product consumption behavior during Covid-19. Lastly, it was found that panic buying has a negative influence on emotional well-being of consumers. Implications of our findings for theory and future research directions are provided.

pH plays a pivotal role in influencing various aspects of proton-coupled electron transfer (PCET) reactions in electrochemical systems. These reactions are affected by pH in terms of mass transport, electrochemical double layer (EDL) structure, and surface adsorption energy, all of which impact the overall electrochemical processes. This review article aims to provide a comprehensive understanding of the research progress made in elucidating the effects of pH on different electrochemical reactions, the hydrogen evolution reaction/hydrogen oxidation reaction (HER/HOR), oxygen reduction reaction/oxygen evolution reaction (ORR/OER), and carbon dioxide reduction reaction ( CO2RR). To embark on this endeavor, we have conducted a bibliometric analysis to clearly outline of the research trends and advancements in the field concerning the pH effects. Subsequently, we present a systematic overview of the mechanisms governing these reactions, with a special focus on pH’s influence on both the proton and electron aspects. We conclude by discussing the current challenges in this area and suggesting future research avenues that could further our understanding of pH's role in electrochemical reactions.

Although most strains of escherichia coli (E. coli) are harmless, some serotypes can cause serious food poisoning in humans. It is very difficult to eliminate E. coli from our lives. Here we show that E. coli can be eliminated by hydroxyapatite (HAp). Because HAp has a positive charge, the material and E. coli are attracted through electrostatic interactions. Additionally, because the surface of HAp is porous, it enters the pores of the HAp surface removing them from the environment. The amount of adsorption was observed to increase over time, and the zeta potential value of the material tended to be similar to that of E. coli. This phenomenon is thought to have zeta potential similar to that of E. coli as it is adsorbed onto the HAp surface over time. E. coli stained with crystal violet was spread on a glass slide and HAp porous sol powder was dropped to remove the E. coli. We expect that this analysis will open a new direction for antibacterial materials.