This study was in line with consecutive growth of urban agriculture implemented to provide a functional vegetable garden model for urban vegetable gardeners. It targeted the users who actually raise functional vegetable gardens, analyzed the flaws for correction in many ways including a type of products, quantity, ratio, and the like and existing problems. It is found out from Utilization that first is the highest ranking with no experience of growing vegetable garden education while growth education helping vegetable garden activity takes the half. Saying yes to the participation in the growth education following the process ranked the highest. In addition when planting, in regards to earning information about plantation timing and measure, they responded that they directly determine those by themselves. Second, the type of plant that they are mainly supposed to produce in family gardening was vegetables. Many say that it is easy to produce, easy to get information. In the fall, Kimchi and vegetables ranked the highest, the reason for functional vegetable gardeners to participate in planting family garden is an interest in a variety of producing crops. Third, the current amount included is proper for flower･herb plants in functional vegetable garden model while the ratio of crops vegetables60.5 : medical21.2 : flower･herbs18.3 in vegetable garden model is responded moderate.

Background: Prenatal exposure to infectious and/or inflammatory insults can increase the risk of developing neuropsychiatric disorder such as bipolar disorder, autism, and schizophrenia later in life. We investigated whether Valeriana fauriei (VF) treatment alleviates prepulse inhibition (PPI) deficits and social interaction impairment induced by maternal immune activation (MIA).Methods and Results: Pregnant mice were exposed to polyriboinosinic-polyribocytidilic acid (5㎎/㎏, viral infection mimic) on gestational day 9. The adolescent offspring received daily oral treatment with VF (100㎎/㎏) and injections of clozapine (5㎎/㎏) for 30 days starting on the postnatal day 35. The effects of VF extract treatment on behavioral activity impairment and protein expression were investigated using the PPI analysis, forced swim test (FST), open field test (OFT), social interaction test (SIT), and immunohistochemistry. The MIA-induced offspring showed deficits in the PPI, FST, OFT, and SIT compared to their non MIAinduced counterparts. Treatment with the VF extract significantly recovered the sensorimotor gating deficits and partially recovered the aggressive behavior observed in the SIT. The VF extract also reversed the downregulation of protein expression induced by MIA in the medial prefrontal cortex.Conclusions: Our results provide initial evidence of the fact that the VF extract could reverse MIA-induced behavioral impairment and prevent neurodevelopmental disorders such as schizophrenia.

Background : Our animal model of stress contained two components: (1) acute trauma, immobilization of rats in close proximity to a cat twice in 10 days, and (2) chronic social instability, 31 days of randomized housing of cage cohorts. Here we tested the hypothesis that daily social stimulation would block the development of the stress. Methods and Results : Beginning 24 h after the first cat exposure, adult male rats were given our established stress model, alone or in conjunction with daily social stimulation, in which all rats within a group interacted in a large apparatus for 2 h each day for the final 30 days. All behavioral, for example, anxiety, memory, startle testing, and physiological assessments, for example, body growth, organ weights, and corticosterone levels, took place following completion of the psychosocial stress period. Conclusion : From the above study, V. fauriei possess significant anti-stress properties and can be used for the treatment of stress-induced disorders.

Changes in temperature and humidity inside a concrete has correlation with movement speed and reaction rate of deterioration factors such as carbon dioxide and chloride ions. comparison was performed between temperature and relative humidity inside the concrete and meteorological data for exposure environment through measurement at the site for two years.

Submerged concrete is subjected by water pressure. Unfortunately, there is a definite lack of well-established research to deal with the effect of permeability on chloride penetration in concrete. This study developed new modeling to predict chloride penetration in submerged concrete subjected to various water pressures.

In this paper, the finite element analysis of RC frame with concrete compressive material models proposed by many researches were conducted. As a results of FEA, the concrete model suggested by Saenz was compatible than other concrete models from the perspective of initial stiffness and maximum strength.

Indices are selected for the evaluation of deterioration of coated steel, and an evaluation method is proposed for each index. The evaluation methods proposed in this study are then applied on the existing inspection data measured on site, and the correlation between the resulting evaluation scores and service life of the coating is derived statistically. This correlation called to as the deterioration model can be used to determine the performance grade for the durability of coated steel.

This research, sponsored by the Korean Ministry of Environment in 2014, was the first epidemiological study in Korea that investigated the health impact assessment of radon exposure. Its purpose was to construct a model that calculated the annual mean cumulative radon exposure concentrations, so that reliable conclusions could be drawn from environment-control group research. Radon causes chronic lung cancer. Therefore, the long-term measurement of radon exposure concentration, over one year, is needed in order to develop a health impact assessment for radon. Hence, based on the seasonal correction model suggested by Pinel et al.(1995), a predictive model of annual mean radon concentration was developed using the year-long seasonal measurement data from the National Institute of Environmental Research, the Korea Institute of Nuclear Safety, the Hanyang University Outdoor Radon Concentration Observatory, and the results from a 3-month (one season) survey, which is the official test method for radon measurement designated by the Korean Ministry of Environment. In addition, a model for evaluating the effective annual dose for radon was developed, using dosimetric methods. The model took into account the predictive model for annual mean radon concentrations and the activity characteristics of the residents

This study was performed to compare the effect of Platycodi Radix (PG) and Black Platycodi Radix (BPG; developed from fresh Platycodon grandiflorum root by steaming nine times at 80°C for 36 hr and drying nine times at 30°C for 24 hr , at which point it becomes black in color.) on anti-oxidant effect, anti-bacterial properties and ovalbumin (OVA)-induced allergic asthma mouse model by calculating serum cytokines and IgE. To induce the allergic asthma, in the control group and the sample treated group, mice of each group were sensitized intraperitoneally with OVA solution at the 1st, the 7th and the 14th day. Sensitization was performed by aerosol allergen challenges with 1% OVA solution intratracheally at the 21th, the 23th, the 25th and the 27th day. At the 29th day, the mice were killed and the levels of interferon-γ, interleukin-4, 5 and 10, total IgE and OVA-specific IgE were measured. IFN-γ was not different among the PG, BPG, and control groups. IL-4, IL-5, IL-13, total IgE, and OVA-specific IgE were significantly in the BPG group compared with the control group. Considering the above experimental results, this study showed that nine times-repitative steaming process on the roots of Platycodon grandiflorum could enhance reduction of the allergic reaction by reducing level of OVA specific IgE and immune cell infiltration and restoring Th1/Th2 cytokine imbalance.

소핵시험은 세포분열 단계 중 간기 세포의 세포질 내 소핵 유무를 조사함으로써 유전독성을 평가하는 시험법이다. 최근 화장품 안전성 평가에 동물실험을 금지하거나 최소화하려는 노력이 확산되고 있어 유전독성 평가에 있어서도 기존의 동물실험이 아닌 새로운 in vitro 시험법이 요구되고 있다. 본 연구에서는 3차원 배양 인공피부모델인 KeraSkinTM을 이용하여 도포 처치된 물질의 유전독성을 평가하였다. 2종의 유전독성물질인 mitomycin C (MMC)와 methyl methanesulfonate (MMS)는 농도 의존적으로 세포독성과 소핵 형성이 유도 된 반면, 대조물질인 4-nitrophenol (4-NP)와 trichloroethylene (TCE)에서는 농도 의존적으로 세포독성은 관찰되었으나 소핵은 형성되지 않았다. 따라서 인공피부모델을 이용한 소핵시험이 화장품과 같은 피부적용물질 의 in vitro 유전독성 평가에 유용할 것으로 사료된다.

최근 남성성탈모증에 대한 관심이 증대되고 있으며, 이에 천연물 및 그의 활성성분을 활용한 새로운 약물 개발에 대한 연구가 증가하고 있다. 송지(Resina Pini, RP)는 Pinus sp. (Pinaceae)의 수지질로 전통의 학적으로 감염, 우식증, 치주질환에 사용되어왔다. 본 연구진은 RP의 성분인 아비에트산(abietic acid, AA)이 남성성탈모기전에 중요한 효소인 5α-reductase를 억제하는 효과를 세포 수준에서 입증한바 있으며, 이번 연 구에서는 실제로 탈모억제 및 모발 성장에 대하여 실험동물 수준에서 입증하고자 한다. C3H/HeN 탈모마우스 모델에서 RP는 300 mg/kg에서 유의하게 탈모억제를 확인하였으며, 뿐만 아니라 AA는 30 mg/kg에서도 유의 하게 탈모억제효과를 보였다. 이상의 결과로부터 RP는 그 활성성분인 AA가 5α-reductase 억제하는 기전을 통해 남성성탈모억제효과를 보였다고 사료되며, 향후 탈모억제 보완치료법으로의 이용 가능성을 보였다.

The initial and boundary conditions are important factors in regional chemical transport modeling systems. The method of generating the chemical boundary conditions for regional air quality models tends to be different from the dynamically varying boundary conditions in global chemical transport models. In this study, the impact of real time Copernicus atmosphere monitoring service (CAMS) re-analysis data from the modeling atmospheric composition and climate project interim implementation (MACC) on the regional air quality in the Korean Peninsula was carried out using the community multi-scale air quality modeling system (CMAQ). A comparison between conventional global data and CAMS for numerical assessments was also conducted. Although the horizontal resolution of the CAMS re-analysis data is not higher than the conventionally provided data, the simulated particulate matter (PM) concentrations with boundary conditions for CAMS re-analysis is more reasonable than any other data, and the estimation accuracy over the entire Korean peninsula, including the Seoul and Daegu metropolitan areas, was improved. Although an inland area such as the Daegu metropolitan area often has large uncertainty in PM prediction, the level of improvement in the prediction for the Daegu metropolitan area is higher than in the coastal area of the western part of the Korean peninsula.

To prevent increasing instances of heat-related illnesses due to heat waves generated by climate change, a customized thermal environment index should be developed for outdoor workers. In this study, we conducted sensitivity analysis of the Masan harbor during a heat wave period (August 9th to 15th, 2013) using the MENEX model with metabolic rate and clothing-insulation data, in order to obtain realistic information about the thermal environment. This study shows that accurate input data are essential to gather information for thermophysiological indices (PST, DhR, and OhR). PST is sensitive to clothing insulation as a function of clothing. OhR is more sensitive to clothing insulation during the day and to the metabolic rate at night. From these results, it appears that when exposed to high-temperature thermal environments in summer, wearing highly insulated clothing and getting enough rest (to lower the metabolic rate) can aid in preventing heat-related illnesses. Moreover, in the case of high-intensity harbor work, quantification of allowed working time (OhR) during heat waves is significant for human health sciences.

최근 들어 역량기반의 교육요구분석과 관련한 연구에서 예비교사와 같이 아직 현장 경험이 충분하지 못한 대상자에게까지 연구대상의 범위가 점점 확대되고 있으나, 교육요구 파악을 위 한 우선순위결정방안은 기존의 경험이 풍부한 대상자에게 적용했던 방식과 동일한 방식을 적용하고 있다는 점에 의문을 제기하였다. 이에 배경지식과 경험의 정도에 따라 보다 타당한 교 육 우선순위를 결정하는 수정모델을 제안하고자 한다. 이러한 연구 목적을 달성하기 위해 경험학습자라고 할 수 있는 현직교사와 아직 교직경험이 없는 미경험학습자인 예비교사를 대상으로 연구를 진행하였다. 먼저, 현직교사와 예비교사가 인식하는 스마트교원역량의 중요도에 대한 순위 차이를 검증한 결과, 전체 13개 역량 중 10개 의 역량에서 유의미한 차이를 나타내고 있음을 확인하였다. 이에 기존에 교육요구분석에서 사 용되었던 대응표본 t 검정, Borich 요구도 공식, The Locus for Focus 모델을 적용하여 스마트 교원역량에 대한 교육요구분석을 실시한 결과, 예비교사의 경우 창의적 문제해결, 내용전문성, 대외협력관계 형성의 순으로 나타났고, 현직교사들은 대외협력관계 형성, 평가 및 성찰, 수업설 계 및 개발의 순으로 나타났다. 즉, 동일한 역량에 대해 예비교사와 현직교사 간 큰 인식차이 가 있음을 나타내 주는 결과로, 이는 역량에 대한 중요도 판정에 기인하는 것으로 나타났다. 본 연구의 결과는 교육요구분석에서 응답자의 배경지식과 경험에 대한 이론적 고찰을 통해 응답자의 배경지식과 경험이 결과해석에 중요한 영향을 미치는 것을 밝혀냈다는 점 과 미경험학습자를 대상으로 하는 교육요구분석에 보다 적합한 모델을 제안했다는 점에서 시사점을 가진다.

본 논문에서는 프랙탈 부호화시 변환식의 계수를 찾는 과정에서 블럭의 탐색 영역을 줄이기 위해 탐색 영역인 도메인블록의 특성을 화소의 밝기의 평균에 의한 클래스와 분산에 의한 클래스로 분류하여 리스트를 구성한 후 레인지블록과 같은 클래스를 가지는 도메인블록만 검색하도록 하면서 도메인블럭 탐색시 1 차 허용 오차 한계값을 제어하여 부호화 시간을 향상시켰다. 또한 쿼드트리분할법으로 레인지블록의 크기를 가변시켜 변환( w i )의 수를 줄임으로서 압축효율을 높이고 레인지블록의 크기에 따라 탐색 영역의 탐색 밀도를 변화시켜 화질 개선을 시도하였으며 이러한 영상 기법을 24-bpp 컬러 영상 압축에 적용하였다. 먼저 RGB표색계를 휘도신호와 채도신호를 가지는 YIQ표색계로 변환한 후 영상 정보의 일부분만 차지하고 있는 색의 정보를 나타내는 I,Q신호는 공간평균을 취하여 1/4로 축소하여 부호화하고 복원시에 선형 보간법을 이용하여 다시 원 영상으로 확대하였다. 그 결과 영상의 화질에는 거의 손실이 생기지 않았고 서로 독립성이 강한