PRK -5000 Auto Ref-Keratometer(Potec Co.) 의 임상성능을 비교 분석하기 위하여 54 명(1 08 안)을 대상으로 자동굴절검사 자각식굴절검사 자동각막콕률측정 및 수동각 막곡률측정을 실시하였다. 굴절이상도 및 각막곡률 측정값을 디옵터굴절력 매트럭스 로 전환하였다. 통일한 대상을 최소 1 일 간격을 두고 2 회 측정한 자동굴절검사 측정값의 Tcst 와 Retest의 평균은 PRK• 5000 및 Control 자동굴절계 모두 유의한 차이가 없었으며， 자 각식 굴절검사값과 자동굴절검사값의 차이 는 등가구면 (PRK -5000, 0.120 :t 0.438D ; Control, 0.120 土0.365Dl, 회 선성분 (Control ， 0.098 :t 0.166D) 및 수직 성분 (PRK-5000 ， 0.262 :t 0.484D; Control. 0.228 :t 0.429D) 에서 유의하였다 .95% 일치구간은 등가구면 (PRK-5000, • 0.738 -_ +0.978D, Control, -0.595 ~ +0.835D) , 수평성분 (PHK -5000, -0,986 ~+0.942D， Control, -0， 773~+0.799Dl 빚 수직성분 (PRK -5000, -0.687 ~ + 1.21ID, Control. 0.613 ~ + 1. 069D) 에서 PRK-5000 이 :t0.20D 이내에서 더 큰 것으로 나타났다 또한 각막곡플 측정값의 재현성을 나타내는 Test와 Retest 의 평균은 PRK-5000 빚 Control 자동곡률계 모두 유의한 차이가 없었으며， 수동 및 자동 각막곡률 측정값의 차이 는 mean K(PRK -5000, -0,087 :t 0.12ID; Control, 0.1 16 :t 0.128DJ, 수평 성 분 (PRK-5000, • 0.051 :t 0.153D; Control, • 0.061 :t 0.144Dl, 회 선 성 분 (PRK← 5000， 0.098 :t 0.256D) 빚 수직 성 분 (PRK -5000, 0.l 28 :t 0.193D; Control, 0,302 :t 0 .1 8ID) 에 서 유의 하 였다. 95% 일치구간은 회선성분 (PRK-5000， -0.404~+0.60ID ， Control, -0.380~ +0.326) 에서만 PRK-5000 이 :t0.15D 정도 더 큰 것으로 나타났다. 이상의 결과를 종합하면 PRK -5000 Auto Ref- Keratometer의 굴절이상도 및 각막 곡률 측정값에 대한 신뢰도와 정확도플 분석한 결과， 자각식 꿀절검사를 섣시하기 전 에 피검자의 굴절이상을 대략적으로 평가할 수 있는 자료플 얻고， 수동 케라토 u1 터룹 대신하여 콘택트렌즈를 피팅하거나 각막의 형상을 분석하기 위해 각막곡률을 측정하 는데 적 절하게 활용될 수 있는 것으로 사료된다.

The adenomatoid odontogenic tumor(AOT) is a benign tumor of odontogenic epithelium characterized by slow but progressive growth and rare recurrence. Tumor growth may cause displacement of teeth rather than root resorption. The AOT appears in 3 clinicotopographic variants such as follicular, extrafollicular, and peripheral. The follicular AOT mimics a dentigerous or follicular cyst and the extrafollicular cyst does a residual cyst, globulo-maxillary cyst and lateral periodontal cyst. Although over 750 cases of AOT were reported in the literature, clinicopathologic parameters of AOT in Koreans has not been investigated. 22 cases of AOT were retrieved from the files of the department of Oral Pathology, Seoul National University Dental Hospital and their clinicopathologic findings were reviewed. The central type accounts for 95%, 72% of which are follicular. The follicular and extrafollicular varients together are more commonly found in the maxilla than in the mandible with a ratio of 4.5:1. Age distribution showed that 59% of AOTs were diagnosed in the second decade of life, and mean age was 18.5 years. The female to male ratio was 3.4:1. All variants of AOT showed identical histologic features.

The p16 gene encodes an inhibitor of the cyclin-dependent kinase, which inactivates cyclin-dependent kinase and contro1s the cell cycle progression, The 10ss of p16 expression or overexpression has been reported in many kinds of tumors, Both p16 and PCNA regu1ates cell cycle progression at the Gl/8 checkpoint, Although many researches about the p16 expression in ora1 cancer have been carried out, there are few studies about the corre1ation between p16 ex pression and pro1iferation of ora1 cancer cells The object of this study was to eva1uate the avai1ability of p16 as ear1y diagnostic factor and prognostic factor through corre1atión ana1ysis of p16 expression in ora1 squamous cell carcinoma and its re1ation to PCNA index and clinicopatho1ogic factors 80 we investigated p16 immunohistochemica1 expression of 83 ora1 squmaous cell carcinomas, and obtained the resu1ts as followed, 18 out of the 83 cases(21, 69%) showed p16 positive and 65 samp1es(78,31%) showed p16 negative, Whi1e the mean va1ue of PCNA indices of p16 positive cases was 65,94 ::t 18,32, that of PCNA indices at p16 negati ve ones 54,79 ::t 18, 39, This difference between them showed statistica1 sígnificance, (P=O, 030) p16 positive group was 12/60(20, 0%) of well differentiated tumors and p16 negative group was 6/23(16, 1%) of moderate1y or poor1y differentiated tumors, This difference did not show statistica1 significance. (P=O. 372) From the resu1ts above, it was suggested p16 expression is re1ated to PCNA index in ora1 squamous cell carcinomas.

We assessed whether the use of a symmetrical upper limb motion trainer in daily repetitive training for a 6-week period reduced spasticity and improved motor function in three chronic hemiparetic patients. Upper limb motor impairment and disability were measured by the Fugl-Meyer Assessment (FMA), Modified Ashworth Scale (MAS) and Manual Muscle Test (MMT), respectively. The electromyography (EMG) of the affected hand was recorded during isometric wrist flexion and extension. In all patients, FMA and MMT scores were significantly improved after the 6-week training. However, MAS scores of the affected wrist spasticity did not change considerably. Onset and Offset delays in muscle contraction significantly decreased in the affected wrist. The co-contraction ratio of flexor and extensor muscles significantly increased after the 6-week training. Onset and offset delays of the muscle contraction and co-contraction ratio correlated significantly with the patients' FMA. This study showed that repetitive, symmetric movement training can improve upper limb motor functions and abilities in chronic hemiparetic patients. Also, the EMG assessment of motor response is likely to provide insights into mechanisms and treatment strategies for motor recovery in chronic hemiparetic patients.

경기도 00읍 및 전라북도 /::，/::，시에 거주하는 60세 이상(평균 나이 : 72.05 ::t 5.768 세)의 노인중 시력장애를 원인으로 2003년 11 월 1 일부터 2004년 4월 30 일 사이에 안 경원을 방문한 355 명(남: 171 명， 여 : 184 명)을 대상으로 안질환 및 일반질환과 함께 교정 전 · 후의 시력을 검사하여 분석하였다. 시력장애의 가장 큰 원인은 굴절이상으로 전체의 56.3% 로 나타났으며， 유형별로 살펴보면 원시가 17.3%, 원시성 난시가 25.1%, 근시가 4.3%, 근시성 난시가 13.1% 그리고 혼합성 난시가 1.4% 로 나타났다. 자각식 굴절검사에 의한 등가굴절이상도는 +0.38 ::t 2.14D( 남 : +0.42::t 1.97D, 여 : +0.35 ::t 2.3 lD)로 나타났으며， 남 · 녀 사이는 5% 수준에서 통계적으로 유의한 차이가 나타나지 않았다 (t = 0.492, p = 0.623). 시력장애의 두 번째 큰 원인은 백내장으로 전체의 20.2%를 차지하였다. 교정 전 · 후의 시력 분 포를 분석한 결과 남자 (t = -33.849, p = 0.000) 와 여자 (t = -32.299, p = 0.000) 모두 5% 수준에서 통계적으로 유의한 차이가 나타났다. 굴절이상을 교정하거나 백내장 수술만으로도 노인인구의 시력 향상의 효과가 크므 로 건강하고 활력있는 인간적 노후생활을 보장하기 위해서는 시력장애의 예방관리 및 조기치료 등을 할 수 있는 기회가 제공되어야할 것이다.

목적 : 임상실습교육은 대학에서 배운 이론적 지식을 임상현장에서 적용하고, 응용하는 기술을 익히는 중요한 교육과정이다. 이에 본 연구에서는 임상실습교육에 대한 국내 관련정보를 분석하여 임상실습교육의 효율적인 운영과 체계적인 틀을 마련하기 위한 기초 자료를 제공하고자 한다. 연구방법 : 작업치료(학)과가 개설되어 있는 대학(교)과 임상실습교육을 실시하고 있는 실습기관을 대상으로 임상실습교육에 관한 관련 정보를 파악하여 분석하였다. 결과 : 임상실습교육을 실시하고 있는 학교는 총 24개 대학으로 한 학교당 평균 14.3개소의 실습기관에 임상실습교육을 위탁하고 있었다. 전체학교의 평균 실습시간은 15.1주, 664시간이었고, 실습 시기는 여름방학 14개교, 겨울방학 13개교, 1학기 5개교, 2학기 3개교 순으로 나타났다. 임상실습교육에 참여하고 있는 실습기관은 총 125개소로 조사되었고, 각 실습기관에서 년 중 임상실습교육을 실시한 학교는 평균 2.8개교였고, 학생은 평균 11.4명의 학생을 지도한 것으로 나타났다. 현재 임상실습기관에 소속되어 임상실습교육에 참여하고 있는 작업치료사는 총 359명이었고, 작업치료사의 경력은 3년 이하의 경력을 가진 치료사가 전체의 57.9%를 차지하고 있었다. 전체 작업치료 관련 기관과 실습교육을 담당하는 기관을 비교한 결과 임상실습교육을 하고 있는 기관은 전체의 47.2%였고, 임상실습교육에 참여하고 있는 작업치료사의 전체의 65.3%로 나타났다. 결론 : 국내의 효율적인 임상실습교육의 질적 향상을 위하여 객관적인 기준마련이 시급하고, 이를 효율적으로 관리하여 실습기관의 인적, 물적 자원이 적절하게 분배될 수 있는 시스템의 구축이 필요하다.

목적 : 작업치료(학)과 교수를 대상으로 임상실습에 대한 견해를 조사하여 그 결과를 토대로 임상실습에 대한 교육과정 구성과 실습지도를 위한 기초자료로 활용 하는데 있다. 연구방법 : 2003년 8월 전국대학작업치료 교수협의회에 참석한 전임강사 이상의 교수(총 45명중 32명 참석)를 대상으로 임상실습에 대한 설문을 실시하였다. 배부된 설문 32부 중 총 26부를 가지고 각 응답에 대한 빈도 및 백분율을 구하여 결과를 분석하였다. 결과 : 작업치료 교육 분야의 실습지도에 있어서 우선 임상실습기관선정에 대한 근거를 마련하고 있지 않는 학교가 43%를 차지하고 있는 것으로 나타났다. ‘실습기관에서 실습지도자의 교육 및 지도가 충실히 이루어지고 있다’라는 질문에 응답자의 24%가‘대체로 그렇다’라고 대답하였다. 임상실습기관과 대학과의 연계성을 묻는 항목에서 협동체계가 잘 이루어지지 않고 있다가 46%를 차지하고 있으며 그 이유에는 임상실습기관의 무관심(40%), 교수의 노력부족과 무관심(18%)때문이었다. 임상실습에서 개선되어야 할 사항으로는 ‘임상실습기관의 환경이 좋지 못하다’가 32%를 차지하였고, 임상실습에서 통일되어야 하는 사항으로는 학생평가양식(41%)과 실습기록지(38%), 기준성적 (17%) 등의 순으로 나타났다. 임상실습 기간 동안 학생들에게 적절한 호칭으로는 ～선생(54%), ～실습학생(42%)을 선호하는 것으로 나타났다. 결론 : 대학과 임상실습기관은 새로운 교육 프로그램을 개발과 개발된 프로그램에 의한 교육이 될 수 있도록 지속적으로 노력해야 하고, 교육 프로그램과 실습 평가 방법, 현장실습비용 등의 문제에 있어서도 전체적인 통일된 체계가 이루어져야 한다. 이를 위해서는 통일된 임상실습 지침서가 시급히 개발되어야 할 것이다.

This study analyzes the factors involving clinical practice which have an influence on the satisfaction of students majoring in physical therapy at colleges or universities located in the Pusan and Kyungnam area. We investigated using a self-reporting method 305 students receiving a grade point average between 2.0 and 4.0 and who had finished their clinical practice. We also investigated the characteristics of clinical settings which make up the clinical practice, the general characteristics of the students involved and the characteristics of a clinical teaching method performed by physical therapists versus a teaching method by a professor of a university. The number of students divided according to educational background are as follows: 149 people (48.9% of the total group) were 4 year students, 156 people were 3 year students (51.1% of the total group). Sixty-nine students' or 22.6% of the group were men while women consisted of 236 persons or 77.4% of the group. Four year students had a longer clinical practice period than that of the 3 year students (p<.05). An average satisfaction score of students with their clinical practice was 3.84. The satisfaction scores showed no significant difference between genders, educational backgrounds, and grades. (p>.05). There were no significant differences in the satisfaction score of students with their clinical practice was 3.84. The satisfaction scores showed no significant difference between genders, educational backgrounds, and grades. (p>.05). There were no significant differences in the satisfaction scores regarding the student management system among varying gender or educational backgrounds between the 3 year and 4 year programs. The average satisfaction score with the environment of the physical therapy room was 3.35. And there were no significant differences in the physical therapy room satisfaction score based on sex or educational system (p>.05). The most influential factor of determining clinical practice satisfaction was a student management system of the clinical practice (p<.01). The next most influential factors were the clinical practice period (p<.05), size of facilities (p<.01) and relationship with physical therapists (p<.01) (=.554).

목적 : 본 연구는 현재 실시하고 있는 작업치료 임상 실습의 문제점을 파악하여 보다 효율적인 임상 실습의 운영방안을 마련하고자 한다. 연구방법 : 본 연구에는 2004년 졸업예정자가 있는 11개의 대학(교) 중 2학기에 임상 실습을 실시하는 2개 대학(교)을 제외한 9개의 대학(교)(4년제 2개 학교, 3년제 7개 학교)의 작업치료(학)과 학생을 대상으로 설문을 실시하였다. 총 250부 발송하여 213부 회수되었다. 조사기간은 2003년 10월 5일부터 11월 31까지였다. 분석은 회수된 설문 213부 중 202부를 가지고 카이제곱검정을 사용하였다.결과 : 실습기관의 적합성을 포함한 실습환경에 관한 내용에서 응답자의 89.6% 만족하는 것으로 나타났다. 실습생을 위한 프로그램의 정비와 지도 체계, 실습생 이용 시설과 설비에 대해 응답자의 20 ∼30% 정도가 불만족한 것으로 나타났다. 실습에 대한 만족도를 측정하는 항목에서 80.3%가 긍정적으로 응답하였다. 응답자의 85%가 임상 실습을 통해 전문적인 지식을 획득하였으나 51%는 임상 실습 중에 갈등을 느낀 적이 있다고 하였다.결론 : 본 연구 결과를 통해 작업 치료학생들의 임상 실습이 좀더 체계화된 구조로 이루어져야 야 필요성을 제시하고 있다. 작업 치료는 임상학문이므로 임상 실습 교육이 차지하는 비중이 높기 때문에 향후 임상 실습에 대한 다각적인 연구가 이루어져야 할 것이다.

World Health Organization(WHO) revised the classification of neoplasms and other tumours related to odontogenic apparatus in 1992. The aim of this study was to classify the odontogenic tumors of Korean according to the WHO Histologic classification. A total of 271 cases were reviewed for the study which were diagnosed as odontogenic tumors at the department of Oral Pathology, Yonsei University College of Dentistry for the period from Jan. 1997 to March 2003. Clinical and pathology reports were reviewed & radiographic feature were examined. The following results were obtained : 1. Among 271 cases, 269 cases(99.3%) were diagnosed as benign odontogenic tumors, and the remaining 2 cases(0.7%) were malignant tumors, which were diagnosed as odontogenic ghost cell carcinoma and squamous cell carcinoma ex odontogenic cyst. 2. Four cases were not able to classify into the WHO classification. All of them were belonged to mixed odontogenic tumors; two cases of adenomatoid odontogenic tumor with calcifying epithelial odontogenic tumor, one case of adenomatoid odontogenic tumor with odontoma, odotogenic cyst and one case of ameloblastoma with immature odontoma. 3. The most frequent odontogenic tumour was odontoma(45.2%), followed by ameloblastoma (29.2%), odontogenic fibroma(9.2%) 4. One case of atypical amelobalstoma and one case of calcifying odontogenic cyst with ameloblastic fibroma were not able to subclassify histologically. 5. Male to female ratio of odontogenic tumors was 1.2:!. Odontogenic tumors mainly occured in the first and second decade, occurred twice as much as in the mandible than in the maxilla 6. The odontogenic tumors was discovered by routine oral x-ray examination, whereas the chief complaint of ameloblastoma were swelling, pain. 7. Ameloblastoma, adenomatoid odontogenic tumor, calcifying odontogenic cyst and odontoma were related to the impacted teeth and tooth displacement. The root resorption was frequently observed in ameloblastoma and calcifying odontogenic cyst.

The purpose of this study was to assess the effects of ultrasound on adjuvant-induced arthritis in rats. Adjuvant arthritis was induced in 26 female Sprauge-Dawley rats by the subcutaneous injection of a single dose of .1 mL of Complete Freund's Adjuvant (CFA) (1 mg of Mycobacterium Butyricum suspended in .1 paraffin oil) into the right hind paw. After confirming inflammatory edema and arthritis in the paw 2 weeks later, the arthritic rats were divided into 3 groups, i.e., a control group, a pulsed ultrasound group (Group A), and a continuous ultrasound group (Group B) with 8 rats placed in each group. The rats in Group A were treated with pulsed ultrasound at 1 MHz frequency with .5 intensity in 1 : 4 mode for 3 minutes. The rats in Group B were treated with continuous ultrasound at 1 MHz frequency with 2 intensity in the continuous mode for 3 minutes. The ultrasound treatment was done in the left and right ankles for 2 weeks. Clinical, radiographic and histopathologic findings were then evaluated before and after treatment and yielded the following results. 1. No significant difference was present in body weight between the control group and the treated groups. 2. A statistically significant decrease in the edema of the paw was seen in the rats in Group A that was treated with pulsed ultrasound by 26~29 days after the treatment started (p<.05). 3. According to radiological examination, Group A showed the lowest score in arthritis scale which means it showed a tendency to suppress arthritic inflammation of the left and right hind paws. However, no statistically significant difference was present in the score between the control group, Group A and Group B. 4. According to histopathologic findings, the degree of infiltration by inflammatory cells and hypertrophy of the synovium were less in Group A compared with the control group and Group B. The results of the study show that rats that were treated with the pulsed ultrasound effectively suppressed adjuvant arthritis. However, more effort is needed to objectively prove the effectiveness of ultrasound by developing more sensitive testing methods that could quantitatively evaluate the treatment effects of acute rheumatoid arthritis and by trying out different ultrasound treatment methods.

Odontogenic keratocysts(OKCs) are frequently associated with erupted or impacted tooth. In such instances, the radiographic features simulate those of a dentigerous cyst. The purpose of this study was to evaluate a comparative immunohistochemical expression of Ki-67 as a proliferative marker and apoptotic signals in the OKC associated with or without impacted tooth. In addition, we have also been investigated with regard to the proliferative activity and apoptosis comparing the unilocular and multilocular varieties of the OKC. The material for this study consisted of thirty-two cases of OKCs (OKC with impacted tooth, n=16；OKC without impacted tooth, n=16) and ten cases of dentigerous cysts as a comparison. The results revealed that the proliferative activity and apoptosis of OKCs with impacted tooth was higher than those of dentigerous cysts. However, there was no correlation between Ki-67 immunoreactivity or apoptosis and association with or without impacted tooth in 32 cases of OKCs. In addition, this present study showed that there was no correlation between the unilocular and multilocular varieties of the OKCs in proliferative activity and apoptosis.

Allergic rhinitis is characterized by rhinorrhea, sneezing and nasal obstruction. Allergic rhinitis increases because of developments of diagnostic techniqhe, environmental change, especially industrialization. Recently people have studied on allergic rhinitis. We studied 107 allergic rhinitis patients with SBJ from June. 2002 to December, 2002. There was a significant effect of SBJ on allergic rhinitis. So, we suggested the clinical effect of SBJ on allergic rhinitis.

1999년 6월부터 2002년 4월까지 총 2년 11개월 간 전국에서 발생한 소 유조사산에 대한 임상학적 연구결과는 다음과 같았다. 1. 계절별 소 유조사산 발생은 여름에 다른 계절에 비해 많이 발생하였다. 이는 여름철의 고온 다습한 기후와 낮은 우군관리 집중도에 기인한다고 사료된다. 2. 임신우의 산차별 유조사산 발생 비율을 조사한 결과 산차가 낮은 소에서 많이 발생하였다. 이는 유조사산의 원인이 임신우의 산차수에 있기보다는 산차수가 높은경우 사육되는

This study was performed to evaluate whether vitrification method using ethyle glycol and eletron microscopic (EM) grid could be used far the cryopreservation of human oocytes in ART program. Surplus oocytes were obtained from consented IVF patients. These surplus human oocytes were frozen with our vitrification method, Oocytes were exposed to 1.5M ethylene glycol (EG) in DPBS far 2,5 minutes, followed by 5.5M EG plus 1.0M Sucrose in DPBS for 20 seconds. Then oocytes were transferred onto the EM grid and the grid was plunged into LN2 for storage. For thawing, oocytes containing EM grid were sequentially transferred in 1.0M, 0.5M, 0.25M, 0.125M and 0 M sucrose in DPBS solution at the intervals of 2.5 minutes. Thawed and survived oocytes were provided for ICSI. Embryos from vitrified oocytes were transferred to uterus of the patient on 4 to 5 days after ovulation in natural cycles of on 15 to 17 day of hormone replacement cycles. A total of 370 oocytes from 26 patients were thawed and 159 (43.0%) of them survived. One hundred thirty four oocytes (84.3%) were fertilized normally and 126 pre-embryos were transferred to 26 patients, resulting in 5 clinical pregnancies. The pregnancy rate per transfer was 19.2% and implantation rate was 4.0%. Among the five pregnant, 4 patients delivered 4 healthy babies and the one patient was 32-week ongoing pregnancy. From this results, vitrification using ethylene glycol as cryoprotectant and EM grid is a rapid and simple method that can be effectively applied for the cryopreservation of human oocytes in ART program.