Zoonotic diseases transmitted through interconnected networks of humans, animals, and the environment are intensifying global public health and biosecurity threats under the One Health paradigm. Conventional diagnostic methods— including microbial culture, serological testing, and PCR-based molecular assays—are accurate but time-consuming, equipment-dependent, and difficult to implement in field settings. In this context, CRISPR-based nucleic acid diagnostics have emerged as an innovative tool that enables rapid, sensitive, and specific detection with minimal instrumentation. This review provides a comprehensive overview of CRISPR systems and their diagnostic mechanisms, with a focus on point-of-care detection of zoonotic pathogens such as SARS-CoV-2, Salmonella spp., Listeria monocytogenes, Bacillus anthracis, Brucella spp., Mpox virus, and avian influenza virus. It also discusses field-deployable technologies, including digital CRISPR assays, one-tube platforms, electrochemical biosensors, and portable diagnostic systems aligned with WHO ASSURD criteria. In addition, the review examines practical considerations for applying CRISPR-based diagnostics in veterinary and food safety settings, including reagent stabilization, matrix compatibility, multiplex detection, and integration with data systems. Collectively, these advances position CRISPR diagnostics as a cornerstone of precision disease surveillance and early intervention within the One Health framework. This innovation heralds a new era of intelligent preventive veterinary medicine that aims to break zoonotic transmission cycles and ensure sustainable biosecurity.

This study analyzed 366 serious industrial accidents related to machinery and equipment that occurred over the past three years (2021–2023) to investigate the preventive effectiveness of the Industrial Safety and Health Standards. The analysis focused on key variables such as the type of work (regular/irregular), type of accident (entanglement, fall, crushing, etc.), 4M factors (Man, Machine, Media, Management), and accident preventability under compliance with safety regulations. The results indicate that approximately 75.7% of all accidents could have been prevented through compliance. Irregular work showed both a higher risk of accident occurrence and a statistically significant association with preventability. In particular, ten major types of machinery, including forklifts, cranes, and conveyors, accounted for 57.9% of all cases. In addition, 37.2% of accidents occurred involving equipment without specific safety rules. These results indicate that some provisions of the current regulations do not sufficiently reflect the realities of actual industrial sites. They suggest the need for field-oriented revisions of the regulations that incorporate newly emerging machinery types and the evolving realities of the workplace.

This study analyzed fall accidents involving boatswain’s chairs over the past ten years to investigate their underlying causes and effective preventive measures. The fall accidents in this study were classified according to construction type, work category, and sequence of work. Next, their direct causes were identified by applying the concept of serious injury factor. A focus group interview was conducted with six experts in boatswain’s chair-type scaffolding to derive preventive measures. The results of the investigation indicate that the majority of accidents occurred in maintenance works among construction types, and painting, caulking, and cleaning tasks among work categories. In terms of work sequence, most fall accents occurred while working with descending due to rope defects (loosening, breakage, or insufficient length) and anchorage failures. Based on these findings, two key preventive measures were proposed: (1) installing lifelines as a fail-safe measure to provide safety redundancy, and (2) implementing inherent safety measures to prevent rope defects and failures such as regular inspections, use of high-performance ropes, and ensuring proper anchorage strength. The findings of this study can be utilized in development of effective safety guidelines and policies for boatswain’s chair operations.

기후변화와 식품공급망의 복잡성 증대로 식품 위해요소 의 발생 경로와 패턴이 다변화됨에 따라, 과학적 예측과 선 제적 개입이 가능한 예방형 식품안전 관리체계의 필요성이 대두되고 있다. 본 연구는 기후·환경 요인이 식품 위해요소 에 미치는 영향을 분석함으로써, 기후 민감성이 높은 위해 요소를 식별하고 예측 가능성과 주요 환경인자를 도출하였 다. 아울러 국내외 데이터 기반 위해예측 시스템의 운영 사 례를 비교·분석함으로써, 식품위해예측센터의 실질적 운영 과 역할을 위한 발전방향을 제시하였다. 본 연구를 통해 향 후 식품위해예측센터가 식품안전 정책의 과학화와 지능화 를 이끄는 전략적 플랫폼으로 기능하고, 예방 중심의 관리 체계로의 전환을 유도할 수 있도록 실효적 토대와 정책적 방향성을 제공하고자 한다.

현재 국내에서는 아스팔트 포장의 예방적 유지보수공법의 사용이 미미하며, 시공 기준 또한 부재한 실정이다. 이에 따라 포장가속시 험시설을 활용하여 예방적 유지보수공법 적용에 대한 공용성 변화 분석을 진행하였다. 본 연구에서는 포그씰 A, B 공법에 대해 도포 량을 다르게 시공하여 기능성 인자인 BPN, MPD와 물성 인자인 공극률에 대해 추적조사를 진행하여 공용성 변화를 분석하였다. 주행 횟수의 산정은 가속시험기의 등가단축하중(ESAL, Equivalent SIngle Axle Load)의 관계식을 통해 실제 교통량을 등가단축하중으로 환산 하여 가속시험 주행 횟수를 산정하여 시공 후 공용 1년까지의 성능을 분석하였다. 분석 결과 기능성 인자인 MPD는 차량 주행으로 인 해 점차 감소하였으며, BPN은 시공 직후 포그씰 처리로 인한 미끄럼 저하가 지배적으로 나타났으나 점차 회복되는 것으로 나타났다. 물성 인자인 공극률은 주행 횟수가 증가할수록 포그씰이 포장 표면으로 채워져 공극률이 줄어드는 것으로 나타났다. 도포량별 분석 결과 도포량이 가장 많은 구간에서 저하율이 모든 인자에서 가장 큰 것으로 나타났으며, 두 도포량의 경우 인자별로 미세한 차이는 존재하였으나 대부분 비슷한 경향을 보이는 것으로 확인되었다.

국내 도로 연장은 2023년 기준 115,878km로 매년 증가하는 추세를 보이고 있다. 이중 준공 30년 이상된 노후도로의 비율은 51.5%에 해당하고 있어 도로 유지관리의 중요성이 대두되는 실정이다. 본 연구에서는 아스팔트 예방적 유지보수공법인 포그씰(Fog Seal)을 실 제 공용중에 있는 도로에 적용하여 공용성 변화를 분석하였다. 공용성능 분석을 위해 차량의 휠패스 부분에서 공법당 6개의 코어를 3 차년간 채취하여 공극률 및 바인더 함량 값을 비교하였다. 분석 방법으로는 포그씰 공법을 시공하지 않은 구간을 대조군으로 선정하 여 추적조사 기간에 따른 변화 추이를 분석하였다. 분석 결과, 공극률은 포그씰 시공 이후 지속적인 감소를 보였다. 바인더 함량의 경 우 공용연수가 증가할수록 바인더 함량 또한 점차 증가하는 것으로 확인되었다. 이는 공용연수가 증가함에 따라 차량의 주행으로 인 해 표면에 도포된 포그씰이 점차 도로 표면 및 균열 속으로 스며들어 내부의 공극이 채워지는 것으로 판단된다.

본 연구는 경로당을 이용하는 노인들을 대상으로 ICT기반 치매예방 통합프로그램을 적용하여 활력, 치매두려움 및 치매예방행위에 미치는 영향을 파악하고자 시도되었다. 프로그램 구성은 주 2회, 6주, 회기당 30분 분량으로 총 12회차이며 단일군 전후 실험설계이다. 자료분석은 기술통계, Paired t-test, Pearson's correlation coefficient를 이용하였다. ICT기반 치매예방 통합프로그램은 경로당 노인의 활력과 치매예방행위를 증가시키고, 치매두려움은 감소시키는 것으로 나타났다. 이러한 연구결과를 통해 ICT기반 치매예방 통합프로그램을 경로당 이용노인의 치매예방를 위해 실무현장에서 활용할 것을 권장한다.

목적 본 연구의 목적은 성인 여성을 대상으로 예방적 선불교 명상 프로그램을 실시하고 프로그램의 실시가 심리적 안녕감과 자기자비 증진에 효과가 있는 확 인하는 것이다. 방법 유사실험설계(Quasi-experimental design)를 통하여 성인 여성 실험집 단 19명, 통제집단 23명을 대상으로 하는 프로그램 효과 검증을 실시하였다. 이를 위하여 2023년 2월 2박 3일 예방적 선불교 명상 프로그램을 실시하고, 심 리적 안녕감 척도와 자기자비 척도를 활용하여 사전-사후 검사를 실시하여 프 로그램의 효과를 검증하였다. 결과 첫째, 예방적 선불교 명상 프로그램은 성인 여성의 심리적 안녕감의 하위 요인 중 긍정적 대인관계, 척도 전체에서 유의미한 차이가 있는 것으로 나타났 다. 둘째, 예방적 선불교 명상 프로그램은 성인 여성의 자기자비의 하위요인 중 마음챙김과 척도 전체에서 유의미한 차이가 있는 것으로 나타났다. 결론 본 연구에서 선불교 명상 프로그램은 확고한 불교 교학을 기반으로 이론 과 방법을 연결한 명상 프로그램을 통해 누구든 쉽게 접근이 가능한 예방프로 그램을 실시하고 그 효과를 확인하였다는데 그 의의가 있다.

PURPOSES : The purpose of this study was to evaluate the common performance of asphalt pavements, determine the timing of preventive maintenance, and determine the optimal timing of application of the preventive maintenance methods by analyzing PMS data. METHODS : Using PMS data on asphalt pavement performance on highways, we derived the major damage factors and evaluated them according to the public period and traffic level. Among the factors evaluated, we determined those that could be improved by preventive maintenance, calculated the amount of change annually, and derived the timing of the application of the preventive maintenance method through correlation analysis. RESULTS : Among highway PMS data factors, crack variation was found to affect preventive maintenance, which increased rapidly after five years of performance. Traffic analysis showed that changes increased rapidly in the fifth, sixth, and seventh years when AADT exceeded 20,000, exceeded 10,000, and was under 10,000, respectively. Analysis of the amount of crack variation according to the pavement type showed that crack variation increased rapidly in the overlay section compared to the general AP section. CONCLUSIONS : Crack variation is the performance factor that was expected to be effective in preventive maintenance, and the PMS data showed that the initial application time of the preventive maintenance method varied by one year, depending on the traffic volume.

국내에서 공용중인 교량은 33,177개로 사회기반시설 중 가장 많은 비중을 차지한다. 이러한 교량은 공용하중, 온도, 습도 등에 의해 거더에 신축량이 발생하게 되고, 거더간 유간거리에 대한 안정성을 확보하기 위해 신축이음장치를 설치한다. 신 축이음장치에는 교량의 누수 및 퇴적물 낙하 등을 방지하기 위해 고무지수재를 설치하는 것이 일반적이다. 하지만 이러한 고무 지수재는 다양한 원인에 의해 쉽게 손상이 발생하게 된다. 손상된 고무지수재를 통해 거더의 부식, 교량하부 인명사고 등 다양 한 2차 피해가 발생할 수 있다. 이러한 피해를 예방하기 위해 교량의 유지관리를 수행하고 있지만 고무지수재 특성상 지속적인 교체는 불가피한 실정이다. 따라서 본 연구에서는 기존 신축이음장치에 활용되는 고무지수재의 문제점을 해결하기 위하여 초탄 성 형상기억합금을 활용한 새로운 지수재 개발 연구를 수행하였다. 초탄성 형상기억합금 지수재에 대한 유한요소해석을 수행 및 분석하였으며, 복원 효과를 통해 지속 사용 가능한 지수재 연구를 검증하였다.

Purpose: In countries with a large elderly population, the integrated visiting health care program for the elderly in communities was effective in preventing frailty and reducing medical expenses. Customized preventive health service is essential in a super-aged society. The purpose of this study is to estimate the number of professionals who perform visiting health care for the elderly. Methods: The statistics for the elderly from Statistics Korea and the Visiting Healthcare Performance Report from Korea Health Promotion Institute were employed in the analysis. The elderly were divided into four groups: healthy, pre-frailty, frailty I, and frailty II, according to their health level. Through the focus group interview, the ratio of nurses, physical activity experts, and nutritionists was set at 8:1:1. Results: Three scenarios were classified into minimum, medium, and maximum according to the number of visits. In the case of Seoul, the number of essential professionals was calculated at least from 719 to a maximum of 1,837. Conclusion: Since this study has a limitation in calculating visiting health care experts only by the ratio of nurses, physical activity experts, and nutritionists, future studies should consider experts or professionals in the field of social welfare, oral health, and visiting treatment.

The purpose of this study was to propose useful suggestion by analyzing preventive replacement policy under which there are minor and major failure. Here, major failure is defined as the failure of system which causes the system to stop working, however, the minor failure is defined as the situation in which the system is working but there exists inconvenience for the user to experience the degradation of performance. For this purpose, we formulated an expected cost rate as a function of periodic replacement time and the number of system update cycles. Then, using the probability and differentiation theory, we analyzed the cost rate function to find the optimal points for periodic replacement time and the number of system update cycles. Also, we present a numerical example to show how to apply our model to the real and practical situation in which even under the minor failure, the user of system is not willing to replace or repair the system immediately, instead he/she is willing to defer the repair or replacement until the periodic or preventive replacement time. Optimal preventive replacement timing using two variables, which are periodic replacement time and the number of system update cycles, is provided and the effects of those variables on the cost are analyzed.

Predicting remaining useful life (RUL) becomes significant to implement prognostics and health management of industrial systems. The relevant studies have contributed to creating RUL prediction models and validating their acceptable performance; however, they are confined to drive reasonable preventive maintenance strategies derived from and connected with such predictive models. This paper proposes a data-driven preventive maintenance method that predicts RUL of industrial systems and determines the optimal replacement time intervals to lead to cost minimization in preventive maintenance. The proposed method comprises: (1) generating RUL prediction models through learning historical process data by using machine learning techniques including random forest and extreme gradient boosting, and (2) applying the system failure time derived from the RUL prediction models to the Weibull distribution-based minimum-repair block replacement model for finding the cost-optimal block replacement time. The paper includes a case study to demonstrate the feasibility of the proposed method using an open dataset, wherein sensor data are generated and recorded from turbofan engine systems.

치매는 노화로 인해 인류가 직면한 과제로, 가장 심각한 정신 건강 문제 중 하나입니다. 2020년 기준으로, 치매 인구는 65세 이상 노인 인구의 15.8%를 占합니다. 질병관리본부와 보건복지부는 '3가지 권장(운 동, 식사, 독서), 3가지 금기(금연, 뇌손상, 약물남용), 3가지 실천(건강검진, 소통, 조기치매 발견)' 등 치매 예방의 중요성을 강조합니다. 인공지능 시대에 치매는 개인의 문제가 아니라 가족적 노력을 준비하며 함께 걱정하고 해결해야 할 사회 적 질병입니다. 미세 뇌기능 장애 단계에서 치매 예방이 필요하며, 미세 뇌기능 장애를 적극적으로 발견 할 수 있는 융합 관리 방법, 생활 습관, 운동 방법 등 자연 치유 방법이 대안으로 살펴볼 수 있습니다. 이를 위해 기억력 상실로 치매 예방을 위한 생활 방식과 자연 치유를 사용하는 전인적인 모델이 필요다 고 믿습니다.

본 연구는 지역사회 거주 독거노인의 치매에 대한 지식 및 태도가 치매예방행위에 미치는 영향을 파악하기 위한 조사연구이다. 연구 대상자는 지역사회 거주 독거노인 101명이었으며 자료 수집 은 2020년 1월 2일부터 1월 16일까지 수행되었다. 분석방법은 SPSS/ WIN 24.0을 이용하여 기술통계, 상관관계 및 다중회귀분석으로 실시하였다. 연구결과, 지역사회 거주 독거노인의 치매예방행위는 치매 지식(r=.42, p<.001)과 유의한 정적 상관관계를 보였다. 치매예방행위에 영향을 미치는 요인은 운동(β =-.26, p=003), 주관적 건강상태(β=.26, p=.003), 치매에 대한 지식(β=.37, p<.001)으로 나타났으며 모형의 설명력은 28.7%이었다. 이에 지역사회 거주 독거노인의 치매예방행위를 향상시키기 위해서는 운 동과 주관적 건강상태 및 치매에 대한 지식을 향상시킬 수 있는 치매예방교육 중재 개발을 제안하는 바 이다.

Declined salivary gland function is commonly observed in patients with diabetes. Advanced glycation end products (AGEs) are believed to contribute to the pathogenesis of diabetes-induces hypofunction of the salivary glands. Polydatin (resveratrol-3-O-β-mono-D-glucoside) is a polyphenol that can be easily accessed from peanut, grape, and red wines. Although polydatin is known to have anti-glycation, anti-oxidation, and anti-inflammation effects, its effect in the salivary gland is not known. In the present study, we evaluated the AGEs burden in the salivary gland in streptozotocin (STZ)-induced diabetic rats and the protective effect of polydatin on diabetes-related salivary hypofunction. Polydatin (50 and 100 mg/kg/day) was orally administered in the STZ-induced diabetic rats for 4 weeks. The results showed that the salivary flow rate of the STZ-induced diabetic rats was reduced compared with that in the normoglycemic control rats. The circulating AGEs in serum and secreted AGEs in saliva increased in the STZ-induced diabetic rats. The reactive oxygen specises (ROS) were highly generated in the salivary gland in these diabetic rats. The salivary gland from the diabetic rats showed increased acinar cell apoptosis compared to normoglycemic control mice. However, polydatin suppressed all of these diabetes-related salivary changes. Overall, polydatin could provide a beneficial option for diabetes-related salivary hypofunction.

목적 : Photobiomodulation 요법은 저출력 레이저 치료기술로, 당뇨망막증, 연령관련황반변성, 망막색소변성증을 포함한 퇴행성 망막질환에 대한 비침습적 치료법으로 제안되고 있다. 최근 광원으로 LED가 널리 사용되고 있으나, 망막에서 LED 기반의 Photobiomodulation에 대한 연구는 매우 부족한 실정이다. 본 연구의 목적은 670 nm LED 광원을 사용한 Photobiomodulation의 망막신경퇴화 억제효과를 조사하기 위해 시행되었다. 방법 : 670 nm LED패널, 반도체 냉각장치, 빛세기 제어기로 구성된 LED 기반의 빛 조사장치를 제작하였다. 망막신경퇴화 유도를 위해 NaIO3를 마우스에 복강주사하였다. 마우스 동공을 확대시킨 후 60 mW/cm2 출력에서 2분 동안 조사하였다. 망막의 광수용세포 손상은 바깥핵층의 두께, 광수용세포 사멸, 광수용단백질인 Rhodopsion, Opsin의 발현, 염증성 사이토카인 유전자의 발현, 뮐러세포의 반응성 신경교증 활성을 통해 분석되었다. 결과 : NaIO3에 의해 손상된 망막에 670 nm LED 빛의 조사는 망막 바깥핵층의 두께 증가, 광수용세포의 사멸 억제, 뮐러세포의 반응성 신경교증 억제, 광수용단백질의 발현 증가를 야기하였다. 결론 : 본 연구는 670 nm LED를 이용한 PBM은 망막 광수용세포의 퇴화를 손상자극 없이 효과적으로 억제할 수 있다는 것을 제시하며, 퇴행성 망막질환 치료에 새로운 전략을 제공한다.

The purpose of this study is to reduce the probability of occurrence of electric fires as a preemptive preventive measure, and to strengthen the capability of preventing electric fires by strengthening the cooperative function between electric fire-related departments and establishing a cooperative system. In this study, the general aspects of electric fires were identified by reviewing the literature such as ignition mechanisms of electric fires. And the major electrical fires that occurred in the last 10 years were classified into ignition factors (short circuit, overload/overcurrent, and earth leakage/ground fault) and ignition sources (wiring/wiring appliances, electrical equipment/household appliances). And the 4M technique was used to analyze the potential causes of ignition at the fire site and to suggest preventive measures. In the case In this study, out of 48 electrical fires in the past 10 years, 16 short-circuit fires, 3 overload/ overcurrent fires, 3 short-circuit and earth fault fires, 16 fires in wiring/wiring appliances, and 10 fires in electrical equipment/home appliances classified as cases. And prevention measures were presented in terms of human, machine, media, and management by using the 4M technique. For the preemptive prevention of electric fires, strengthening the compulsory electrical safety inspection and making it mandatory to report when new or expanding electric facilities, charging a fee for electric safety inspection for detached houses and granting benefits subject to inspection completion, improvement of the electric safety voluntary inspection table and safety indications; It was suggested as a policy to organize and operate electrical safety inspection personnel in a two-person team (mixed), establish a close work cooperation system with related organizations, and strengthen electrical safety education and publicity.

본 연구는 중년기 성인의 치매태도와 예방행위에 대해 조사하고 이들 간의 관계를 파악하기 위한 서술적 조사연구이다. 연구대상자는 일개지역 G시에 거주하는 중년기 성인 146명이며, 구조화된 설문지를 이용하여 2019년 11월부터 12월까지 자료를 수집하였다. 자료분석 방법은 SPSS/WIN 24.0 프로그램을 이용하여 빈도와 백분율, t-test, ANOVA, Pearson's correlation coefficient로 분석하였다. 연구 결과 중년기 성인의 치매태도는 50점 만점에 35.08점, 예방행위는 36점 만점에 29.02점으로 나타났다. 치매태도는 직업에서 유의한 차이가 있었고(t=2.13 p<.05), 예방행위에서는 치매조기예방 관심(F=29.39, p<.001), 가족 중 치매환자(t=-2.62 p<.05), 에서 유의한 차이가 있었다. 치매태도와 예방행위는 유의한 양의 상관관계(r=.281, p<.001)로 나타났다. 따라서 중년기 성인의 치매에 대한 예방행위를 증진시키기 위해서는 치매에 대한 긍정적인 태도 및 치매예방에 대한 생활습관 관리의 중요성을 강조하는 교육 프로그램 개발이 필요하다.

본 연구는 코로나19 유행 시기 간호대학생의 코로나19에 대한 불안, 위험인식, 정보이해력, 감염예방행위 이행 수준을 파악하기 위해 시도되었다. 본 연구는 서술적 조사연구로 2020년 6월 8일부터 6월 14일까지 간호대학생 224명을 대상으로 온라인을 통해 설문조사를 실시하였다. 수집된 자료는 SPSS 26.0을 이용하여 기술통계, t-test, ANOVA, 상관관계 분석을 하였다. 간호대학생의 불안정도는 6.86점(최대10점)으로 보통 수준이었으며, 위험인식은 8.19점(최대10점), 정보이해력은 3.50점(최대4점), 감염예방행위 수행정도는 4.44점(최대5점)으로 높은 수준이었다. 감염예방행위는 불안정도, 위험인식, 정보이해력이 높을수록 수행정도가 높았다. 코로나19와 같은 신종감염병이 유행할 때는 감염에 대한 불안감과 위험인식이 증가할 수 있으므로 감염병에 대한 충분한 정보제공으로 감염병에 대한 정확한 이해가 필요하다. 신종 감염병에 대한 정확한 이해는 철저한 감염예방행위를 향상 시키므로 감염병 전파 위험을 감소시킬 수 있을 것이다.

전 세계 90 %의 인구가 WHO의 연평균 미세먼지 노출 기준(10 ㎍/㎥)을 초과한 공기를 흡입하고 있다. 전 세계적으로 육상뿐 만 아니라 해양에서 발생하는 질소산화물에 대한 규제를 통해 2차 오염물질, 초미세먼지 저감에 대해 노력하고 있으며 국내에서는 선박에서 미세먼지 발생의 주요한 원인인 황 함유량 저감과 환경친화적 선박의 개발 및 보급 등을 통해 깨끗한 해양환경 조성을 위한 노력을 하고 있다. 디젤엔진 유해 배출가스 저감을 위한 기술 중 압력 손실이 적고 높은 집진 효율 및 NOx의 제거와 유지 관리의 장점이 많은 전기 집진기의 수요와 중요성이 증가하고 있다. 본 연구는 총톤수 999톤급 선박의 2,427 kW 선박용 디젤엔진의 미세먼지 저감을 목적으로 개발된 전기 집진기를 예지보전단계에서 고장모드영향분석을 통해 장비 품질을 높여 선박 내에서의 내구연한을 높이고자 위험 우선순위 도출하였다. 위험 우선순위는 고장모드 241(poor dust capture efficiency)이 RPN 180으로 가장 높았다. Collecting electrode 에서 가장 많은 고위험 고장모드를 검출하여 집중관리 부품으로 관리해야 할 필요가 있었으며 원인으로 진동과 핀 풀림으로 인한 유 격 불량이 가장 많이 검출되었다. 핀 풀림 역시 근본적으로는 선체 또는 장비에서 발생하는 진동이 원인이 되어 발생할 수 있는 사항이기 때문에 핀 풀림이 발생하는 개소에 보완이 필요하겠다.

The milk fever and mastitis that occur during the colostrum period in dairy cattle cause great damage in the dairy industry by causing a rapid decline in the cattle’s health and decreasing milk production. In order to prevent this, gradual milking (GM), calcium injection with gradual milking (CG), and calcium injection with complete milking (CC) methods are used. However, differences in effectiveness between these methods have not been established. Therefore, this study was conducted to determine the effects of each preventive method on milk fever and mastitis. The results of this study showed that while there was a significant negative correlation of GM with milk fever and mastitis (r = –0.657, p < 0.05), there was no correlation of CG and CC with milk fever and mastitis. The incidence of milk fever was significantly lower in CG and CC than in GM (p < 0.05) but no differences in the incidence of mastitis were observed between the three groups. No significant differences in the rate of recovery from milk fever and mastitis were observed between the three groups. The recurrence rate of milk fever was significantly higher in CG and CC than in GM (p < 0.05), though no differences in the recurrence rate of mastitis were observed. This study showed an inverse relationship between the incidence rates of milk fever and mastitis when calcium injection was not used during the colostrum period. When calcium injections were used, the incidence of milk fever was reduced without affecting the incidence of mastitis regardless of the milking method, but the recurrence rate of milk fever was increased. The results of this study would be useful for controlling blood calcium concentrations and establishing efficient milking strategy in order to effectively prevent milk fever and mastitis in dairy cattle during the colostrum period.

This paper investigates the stress-reducing preventive maintenance model through numerical experiments. The preventive maintenance model is used to analyze the relationship between related conditions and variables to gain insight into the efficient operation of the system when performing preventive maintenance in real-world situations. Various preventive maintenance models have been developed over the past decades and their complexity has increased in recent years. Increasing complexity is essential to reflect reality, but recent models can only be interpreted through numerical experiments. The stress-reducing preventive maintenance is a newly introduced preventive maintenance concept and can only be interpreted numerically due to its complexity, and has received little attention because the concept is unfamiliar. Therefore, for information purposes, this paper investigates the characteristics of the stress-reducing preventive maintenance and the relationship between parameters and variables through numerical experiments. In particular, this paper is focusing on the economic feasibility of stress-reducing preventive maintenance by observing changes in the optimal preventive maintenance period in response to changes in environmental stress and the improvement factor. As a result, when either the environmental stress or the improve effect of stress-reducing preventive maintenance is low, it is not necessary to carry out the stress-reducing preventive maintenance at excessive cost. In addition, it was found that the age reduction model is more economical than the failure rate reduction model.

PURPOSES : The purpose of this study is to evaluate the performance of an ultra-thin asphalt pavement as a preventive maintenance approach through laboratory tests. METHODS : An ultra-thin asphalt pavement of 2 cm wearing course thickness comprising modified asphalt and aggregate is a preventive maintenance method used for asphalt pavements. A mix design was carried out to determine the optimum aggregate gradation and asphalt contents. A dynamic immersion test was performed to evaluate the water-resistance of the ultra-thin asphalt pavement. A wet track abrasion test and a cohesion test were conducted to examine the applicability of the ultra-thin asphalt pavement in surface treatment. The performance of the ultra-thin asphalt pavement was evaluated through wheel loading tests, such as Hamburg wheel-tracking and third-scale model mobileloading simulator (MMLS-3). RESULTS : An optimum binder content of 4.9% was obtained in the ultra-thin asphalt mixture from the Marshall mix design. The waterresistance tests indicated a 70% dynamic immersion coverage rate of the ultra-thin asphalt pavement. The wet track abrasion test showed an abrasion rate of 0.0107 g/cm2, and the cohesion tests indicated a 19.0 kg·cm average cohesion at 30 min of operating time and 21.4 kg·cm average cohesion at 60 min of operating time. From the Hamburg wheel-tracking test, a 16.56 mm rut depth at 20,000 wheel passing was obtained. Finally, a 5.87 mm rut depth at 300,000 number of wheel passing was detected from the MMLS-3 test. CONCLUSIONS : The water-resistance of the ultra-thin asphalt pavement satisfied the recommended guidelines of the Korean Ministry of Land, Infrastructure and Transport. In addition, the applicability of the ultra-thin asphalt pavement as a surface treatment met the standard of the International Slurry Surfacing Association. Furthermore, the deformation performance of the ultra-thin asphalt pavement was 1.5 times better than that of the straight asphalt pavement, based on the results of the wheel-loading tests. Hence, it is estimated that an ultra-thin asphalt pavement has a high performance in the preventive maintenance of asphalt pavement, even though the cracking resistance was not evaluated in this study.

Whole grain cereal (WGC)-rich diets provide macronutrients that are important for the regulation of energy metabolism. The current study evaluated whether WGCs had a preventive effect on sarcopenic obesity in high-fat diet (HFD)-induced obese mice. C57BL/6N mice were fed a normal diet (ND), ND+WGC, HFD, and HFD+WGC for 12 weeks. WGCs significantly reduced body weight gain, food efficiency ratio, fat mass, and adipocyte size in HFD-induced obese mice. WGCs attenuated HFD-induced nonalcoholic fatty liver disease by decreasing liver weight and hepatic fat accumulation. In addition, WGCs increased muscle strength and muscle mass in HFD-induced obese mice as well as in ND mice. Taken together, WGCs can be employed as functional food materials for the prevention of sarcopenic obesity by inhibiting fat accumulation and increasing muscle mass.

본 연구의 목적은 보육교사의 근무 상황을 고려하여 아동학대 예방을 위한 실질적인 예방 대책과 보육환경에서 겪게 되는 인권 보장 대책 마련을 위한 것이다. 정부는 영유아의 건강한 성장과 발달, 그리고 자녀양육에 있어 국가의 역할과 양질의 보육환경 향상에 더욱 관심을 갖고 국가 정책으로 많은 노력과 예산을 사용하고 있다. 아동학대예방을 CCTV에 의존하는 정부의 대책은 근본적인 원인과 해결방법으로 불가능하며 아동학대사건이 발생되기 전 보육교사와 학부모 간에 신뢰와 소통을 회복하기 위한 노력을 해야 한다. 따라서 영유아를 대상으로 보육교사와 학부모가 서로 신뢰를 형성하고 보육환경개선에 대한 보다 적극적인 정부의 노력이 필요하다. 그리고 더 나아가 보육교사 인성교육을 강화하고 정부차원에서 보육교사인권보호에 대해 반드시 노력해야 할 것이다.

As a system complexity increases and technology innovation progresses rapidly, leasing the equipment is considered as an important issue in many engineering areas. In practice, many engineering fields lease the equipment because it is an economical way to lease the equipment rather than to own the equipment. In addition, as the maintenance actions for the equipment are costly and need a specialist, the lessor is responsible for the maintenance actions in most leased contract. Hence, the lessor should establish the optimal maintenance strategy to minimize the maintenance cost. This paper proposes two periodic preventive maintenance policies for the leased equipment. The preventive maintenance action of policy 1 is performed with a periodic interval, in which their intervals are the same until the end of lease period. The other policy is to determine the periodic preventive maintenance interval minimizing total maintenance cost during the lease period. In addition, this paper presents two decision-making models to determine the preventive maintenance strategy for leased equipment based on the lessor’s preference between the maintenance cost and the reliability at the end of lease period. The structural properties of the proposed decision-making model are investigated and algorithms to search the optimal maintenance policy that are satisfied by the lessor are provided. A numerical example is provided to illustrate the proposed model. The results show that a maintenance policy minimizing the maintenance cost is selected as a reasonable decision as the lease term becomes shorter. Moreover, the frequent preventive maintenance actions are performed when the minimal repair cost is higher than the preventive maintenance cost, resulting in higher maintenance cost.

The reinforced retaining wall was introduced in the late 1980s and has been actively used since the 1990s in Korea 's expressway construction. At the beginning of the introduction, proper stiffeners and backfill materials were used and compaction management was thoroughly carried out, which was recognized as an economical and excellent workability method. However, the current understanding of reinforced earth retaining walls about 30 years old is a negative image such as inadequate reinforcement materials, backfill materials, insufficient compaction, and insufficient drainage system. In this way, the reinforced earth retaining walls that have been constructed in the midst of the negative perception are about 1,000 at the expressway site, and about 1000 will be completed in a few years and about 2,000 will be used. Most of the problems of reinforced earth retaining wall were found during maintenance, and countermeasures are suggested by tracing back to what problems were observed in the design and construction of the observed phenomena. The retaining walls to be installed in future maintenance should be minimized in designing and constructing to prevent problems. It is estimated that such a problem can be solved by changing the recognition. Therefore, in this study, damage cases of reinforcement retaining wall which is frequently occurred in the expressway of Korea were analyzed to derive the preventive maintenance method of reinforced earth retaining walls. Then, the problems and countermeasures were analyzed for each type of damage.

This study attempted to establish fire risk factors and preventive measures for each of five major types of construction, focusing on construction sites. For this purpose, disaster cases were analyzed and countermeasures were prepared. In addition, fire risk factors and flammable and combustible materials by construction type according to construction process were identified and preventive measures thereof were suggested. The results of this study can be used to establish policy improvement directions that meet various educational needs and expectations by identifying the use status of flammable and combustible materials and figuring out the fire risk factors according to the process by work type in construction sites.

As a system complexity increases and technology innovation progresses rapidly, it tends to lease a system rather than own one. This paper deals with a decision-making model to determine the preventive maintenance strategy for leased equipment. Various maintenance options are presented and formulated via the non-homogeneous Poisson process. During the lease period, the preventive maintenance strategy that minimizes the total cost among the presented maintenance options is selected. A numerical example is provided to illustrate the proposed model.

PURPOSES:In this study, field performance evaluation of crack treatment of pavement and the feasibility of surface treatment of pavement are presented. The performance and cost of preventive maintenance methods have been previously verified, and the methods are being used in many developed countries and cities. However, the performance and cost of the system have not been verified in domestic, field applications. Therefore, in order to improve performance, the field performance is evaluated, and a reasonable cost is proposed.METHODS:Visual Inspection was conducted to evaluate the field application and performance of the preventive maintenance method. In addition, the PCI index was calculated from the results of visual inspection of the application area of the surface treatment method, and the performance life of each method was predicted. For the economic evaluation, life cycle cost analysis was performed using the life cycle cost analysis program.RESULTS:In order to evaluate and quantify the field performance of crack repair material, the residue condition of the pavement surface after crack treatment, rather than the performance of the material, is evaluated. In addition, the crack resistance and performance life of surface treatment methods are evaluated. The cost of currently available treatment methods are compared to the common pavement cut and overlay method, and it is determined that the preventive method is not economical based on life cycle cost analysis.CONCLUSIONS:Because of the characteristics of cracking, it is necessary to conduct the evaluation of currently applied methods and the analysis of the cause of damage, by visual inspection. Moreover, in order to evaluate the performance and economic suitability of the currently applied surface treatment methods, it is necessary to acquire information on application sections by monitoring their long-term conditions and performance.

프로바이오틱스는 인체 내에서 정상 균총의 역할을 하며 건강에 도움을 주는 미생물을 의미하며, 식품이나 미생물총에서 유래한 비교적 안전한 균주이다. 프로바이오틱스로 많이 사용되는 젖산균은 소화를 돕고 장내환경을 보호해줄 뿐 아니라 면역조절기능 또한 가지고 있다. 대표적으로 Th1 반응을 유도하여 Th1/Th2 균형을 이루게 하는 것을 중심으로, 알레르겐에 반응하는 IgE 및 침윤된 비만세포와 호산구를 감소시키고 면역 억제 기능이 있는 Treg을 유도함으로 알레르기 반응을 완화시킨다고 알려져 있다. 하지만 프로바이오틱스를 이용한 알레르기 질환에 대한 치료 및 예방 효과는 질병 별로 다르게 나타났다. 아토피 피부염에 대해서는 예방 및 치료 효과가 검증되고 있고 알레르기 비염과 음식물 알레르기에서는 예방 효과는 미미했지만 치료효과에서 긍정적이었다. 기관지 천식의 경우 프로바이오틱스의 예방 및 치료 효과를 거의 볼 수 없었지만, 최근에는 특정 균주가 기관지 천식 환자에서 임상 증상을 향상시킨다는 보고가 있다. 균주의 장내생존율을 높이고 재조합 유산균을 만드는 백신 기술과 함께 프로바이오틱스는 미래의 안전한 알레르기 예방 및 치료제로서 기대할 수 있을 것이며 지속적인 시장의 확대를 통해 차세대 건강기능식품으로 떠오를 것이다.

목적 : 본 연구의 목적은 욕창방지용 휠체어 쿠션의 신기술을 소개하고, 이 신기술에 따른 압력이 차이가 있는지를 알아보고자 함이다. 연구방법 : 본 연구는 2015년 6월 18일부터 23일까지 6일간 진행되었다. 일반 성인 남녀 2명을 대상으로 진행하였으며, 실험은 신기술의 욕창방지용 휠체어 쿠션 세 종류를 사용하였다. 각각의 쿠션은 45분간 적용되었으며, 측정된 압력 값을 비교하기 위해 X3 Medical v6.0을 사용하였다. 압력 측정의 맨 첫 번째 구간의 최대 압력 값, 맨 마지막 구간의 최대압력 값, 그리고 첫 번째, 중간, 마지막 구간을 합하여 3으로 나눈 평균 최대 압력 값을 각각 분석하였다. 결과 : 각 쿠션별로 측정된 압력 값을 분석한 결과, Java 쿠션이 최대 압력의 초기, 후기, 평균값 모두 가장 낮게 나타났다. Lock 쿠션은 최대 압력의 후기 값과 평균값이 가장 높았다. Galaxy 쿠션은 최대 압력의 초기 값이 가장 높았다. 결론 : 3가지 쿠션의 각 최대 압력 값이 부위에 따라 다르기 때문에 욕창 예방에 가장 효과적인 쿠션을 결론짓기에는 다소 무리가 있으나, 45분 동안 적용한 기준으로 측정한 최대 압력의 값은 Java 쿠션이 Galaxy와 Lock 쿠션보다 낮게 나타 났다. 그러나 욕창방지용 휠체어 쿠션 세 종류가 가지고 있는 기술의 특성을 고려하였을 때, 명확한 기준을 설정하여 보다 긴 시간동안의 압력 값을 비교하는 연구가 필요할 것으로 예상되며, 일반인이 아닌 실제 휠체어를 장기간 사용하는 대상자로 연구를 진행해볼 필요가 있다.

This study was designed to investigate dietary life related to sodium of participants in hypertension and diabetes preventive education at the public health center located in Incheon Metropolitan City. Subjects were comprised of 301 adults (males: 102, female: 199) of age 50 years and above. The questionnaire for dietary life and salty taste assessment were performed on the subjects. Data were analyzed using SPSS package (ver. 18.0). According to the result of questionnaire for dietary behavior, 70% of the subjects were in the low salt intake group (p<0.001). In the result of questionnaire for dietary frequency, all ages groups were in the low salt intake group (p<0.01). The data of questionnaire for dietary behavior showed that the subjects of age above 75 years preferred salted seafood, soup, and kimchi (p<0.01). The data of questionnaire for dietary frequency showed that the subjects of age between 65 and 74, least chose fried kimchi, noodle, and soybean paste soup with clams (p<0.05), and the healthy adult groups chose kimchi stew, ssam and ssamjang (p<0.05). The score for dietary behavior in male subjects was higher than female subjects (p<0.01). In particular, the score for dietary frequency was the lowest in the subjects of age between 65 and 74 (p<0.01). The mean value of salty taste assessment in the subjects was 0.41% which is higher than the ideal value of 0.3% (p<0.01). Offering more nutrition education and continuous feedback of healthcare center may be needed to improve the health status of the adults.

2014년에 시행된 생물다양성 보전 및 이용에 관한 법률에 따라 외래생물의 사전예방적 관리 제도가 마련되었다. 아직 국내에 도입되지 않았으나 도입될 경우 생태계에 침입하여 부정적인 영향을 줄 수 있는 외래생물 중 포유류, 조류, 어류, 연체동물, 곤충, 식물을 포함한 24종이 위해우려종으로 지정되었다. 위해우려종을 국내로 수입 반입하고자 할 경우에는 환경부장관으로부터 승인을 받아야 한다. 이러한 제도는 기존의 법 체계에 비해 사전관리가 도입되었다는 측면에서 발전한 것이지만, 몇가지 개선해야 할 점이 있다. 첫째, 위해우려종의 범주 확대이다. 현재의 국내에 도입이 되지 않은 외래생물 대상에서, 국내에 도입되어 수족관, 식물원, 동물원 등의 사육 또는 재배시설 안에 제한적으로 존재하며 아직 생태계에는 정착되지 않은 외래생물까지 고려할 필요가 있다. 둘째, 정부에서는 수입 반입 신청자를 위하여 위해 우려종의 생태계위해성심사 세부 기준과 위해우려종이 자연 환경으로 탈출하는 것을 방지할 수 있는 안전관리 지침을 제공하여야 한다. 셋째, 위해우려종의 탈출에 대한 조기 탐지 및 신속 대응 방법 및 프로토콜이 개발되어야 한다.

Materials are limited for pest control and chemical pesticides are prohibited in organic farming. Thus, the concept of pest control may not be effective for pest management in organic farm. As an alternative approach, landscape management is potentially effective and useful approach for preventing pathogen and insect pests in organic farm. It is needed to develop best practices utilizing functional biodiversity for pest management through landscape management. For this purpose, we investigated the effect of companion plants on species richness of insect pests and natural enemies in the field border area and in the crop plants (rice and soybean). In rice paddy fields, Lysimachiae foenum-graecum, Saururus chinensis were selected as effective companion plants on the paddy field levee for conserving Arachnidae as natural enemy and density suppression of insect pest such as Lissorphoptrus oryzophilus, Riptortus clavatus. As a result, damage rate of rice plant by insect pests was significantly lower (2.5%) and yield rate of healthy grains was significantly higher (8.7%) than control. In soybean fields, Marigold plants such as Tagetes patula, T. officinalis, increased Arthropod species richness and ratio of natural enemy group, and decreased ratio of insect pest group. As a result, yield (weight of 100 seeds) of healthy soybean was significantly increased (2.5%) than control. The 2nd infection rate from damage by R. clavatus was significantly lower in the treated plot than that in control. Thus, yield rates of healthy soybean in the control and the companion plant-treated plot were 79.0% and 84.3%, respectively, compared to conventional farming using chemical pesticides. Therefore, use of companion plants on field border was an effective practices for preventing pest insects and increasing yield in organic farming.

PURPOSES: Surface treatment is a favorable method in the pavement preventive maintenance. This study (Part Ⅰ) aimed to develop the low viscosity filling material for waterproof characteristics and high penetrable and weather resistance, and a series of companion study (Part Ⅱ) presents the coating characteristics and performance analysis using field and lab tests. METHODS : Hydrophobic characteristics of the advanced surface treatment material are observed and measured the filling depth and the permeability for sand and asphalt pavement specimen using the water absorption test and permeability test, X-RAY CT test. Color difference for the weather resistance using ultraviolet ray accelerated weathering test is compared with asphalt pavement specimens. RESULTS : The developed material shows the decreased water absorption and increased impermeable effect because of the hydrophobic characteristics. It is found that the filling depth is about 6mm and weather resistance is better than asphalt pavement specimen. CONCLUSIONS: The advanced hydrophobic - low viscosity filling treatment material is developed in this study (Part Ⅰ) to improve the waterproof characteristics and high filling capacity and weather resistance for the pavement preventive maintenance.

PURPOSES : Surface treatment material for pavement preventive maintenance should be inspected field applicability. This study(Part Ⅱ) aimed to checkup coating characteristics and performance analysis using lab and field tests. The hydrophobic - low viscosity filling material for pavement preventive maintenance is presented in Part Ⅰ, which is a series of companion study. METHODS: Relative comparison between general asphalt mixtures and surface treatment asphalt mixtures are analyzed and measured for the field application such as indirect tensile strength ratio(TSR), abrasion resistance, crack propagation resistance, temperature resistance, coating thickness, permeability resistance and skid resistance in terms of british pendulum number(BPN). RESULTS: It is found that TSR, crack propagation resistance and permeability resistance is increased as against uncoated asphalt specimen. Abrasion resistance and temperature resistance is secured from the initial coating thickness point of view, which is about 0.2~0.3mm. Skid resistance on the surface treatment pavement is satisfied with the BPN criteria of national highway because of exposed aggregate and crack sill induced pavement deterioration and damage cracks. CONCLUSIONS : The hydrophobic - low viscosity surface treatment material for pavement preventive maintenance is validated on field applicability evaluation based on quantitative analysis of coating thickness and performance analysis using lab and field tests.

In this study, appropriate preventive measures are suggested as follows by analyzing industrial accident cases occurred for five years of company J and workers’ survey. First, personnel management including meticulous shift work and rotation task for olde

목적 : 본 연구는 작업·물리치료사들의 근골격계질환 유해인자를 확인하고 이에 따른 근골격계질환 예방프로그램의 적용이 통증 및 직무스트레스에 미치는 효과에 대해 알아보고자 하였다.연구방법 : 2010년 5월부터 동년 7월까지 경남 창원에 위치하는 C병원에 근무하는 21명의 작업·물리치료사들을 대상으로 근골격계질환 유해인자를 Quick Exposure Checklist(QEC)를 통해 확인한 후, 이에 따른 근골격계질환 예방프로그램을 8주간 적용하였다. 대상자들의 중재 전·후의 통증과 스트레스 변화를 측정하기 위해 시각적 상사척도(Visual Analogue Scale; VAS)와 한국인 직무스트레스 측정도구를 각각 사용하였다.결과 : QEC를 통해 작업·물리치료사들의 업무환경은 개선이 필요한 수준임을 알 수 있었고, 중재를 적용 후 중재 전에 비해 VAS와 한국인 직무스트레스 측정도구의 결과가 유의하게 감소함을 알 수 있었다(p<.05). 또한 VAS와 한국인 직무스트레스 측정도구의 상관관계 분석을 통해 통증변화와 직무스트레스변화 간에 양의 상관관계가 있음을 확인하였다(p<.05). 결론 : 본 연구는 작업·물리치료사의 업무환경 분석을 통한 근골격계질환 예방프로그램을 적용함으로써 근골격계질환 예방활동이 작업·물리치료사의 통증 및 직무스트레스 감소에 긍정적인 효과가 있음을 제시하였다.

Recently, carelessness on safety management in construction sites has caused a sharper upward trend in accidents and disasters, compared to the past. Therefore, this study analyzes the causes of accidents that occurred on construction sites in the year of 2007, and proposes preventive measures. The construction industry had a heavy death rate with 279 out of 418 deaths from falls in all industrial sites, accounting for 66.7%. And the causation analysis found a particularly high incidence of temporary structure-related accidents, with falling off scaffolding as the most common cause of accidents. According to the causation analysis of fall-down accident cases, accidents induced by protrusion on construction sites are a big contributor resulting in the deaths of 312, accounting for 74.8%, which is deemed to be due to site disorderliness. And to remove floor protrusions and to secure workers' traffic line and safety, neat and thorough site arrangement is necessary. Against collision, efforts must be made to prevent equipment-pedestrian crashes on site, which necessarily requires emergency lamps, alarm bells, and safety poles and blocks to be installed, lighting systems to be improved, obstacles to be removed, site supervisors to be assigned to construction equipment works, and workers to be more intensely trained and supervised.

Recently, carelessness on safety management in construction sites has caused a sharper upward trend in accidents and disasters, compared to the past. Therefore, this study analyzes the causes of accidents that occurred on construction sites in the year of 2010, and proposes preventive measures. The construction industry had a heavy death rate with 279 out of 418 deaths from falls in all industrial sites, accounting for 66.7%. And the causation analysis found a particularly high incidence of temporary structure-related accidents, with falling off scaffolding as the most common cause of accidents. According to the causation analysis of fall-down accident cases, accidents induced by protrusion on construction sites are a big contributor resulting in the deaths of 312, accounting for 74.8%, which is deemed to be due to site disorderliness. And to remove floor protrusions and to secure workers’ traffic line and safety, neat and thorough site arrangement is necessary. Against collision, efforts must be made to prevent equipment- pedestrian crashes on site, which necessarily requires emergency lamps, alarm bells, and safety poles and blocks to be installed, lighting systems to be improved, obstacles to be removed, site supervisors to be assigned to construction equipment works, and workers to be more intensely trained and supervised.

This study carried out the investigation about the actual conditions of the management, disaster analysis and safety awareness on excavator in one of construction equipment and tried to make it's preventive measures. To achieve this, first of all, the accident of the internal Construction Industry process Investigation and Analysis, and then analyze an cause of accident based on it. Next, For the conditions of safety management conduct a survey to Investigation and Analysis and Propose preventive measures. The results of this study can be summarized as follows. 1st, Status of safety awareness and management of construction equipment tend to seek quickly and easily for the interests of sight. 2nd, Half the precincts of the equipment is causing major disaster. 3rd, The risk of excavator operation's indicators and drivers is so much potential. 4th, The preventive measures are needed for strengthening safety education, professional legal education, changes in safety awareness, the development of prevention system.

본 연구에서는 대표적인 퇴행성 신경질환인 알츠하이머성 치매에 대한 마늘 물, 100% 메탄올, 디 클로로메탄 추출물들의 acetylcholinesterase (AChE) 저해 및 신경세포 보호효과를 조사하였다. 마늘 디클로로메탄 추출물은 농도 의존적으로 AChE를 저해하는 것으로 나타났으며, IC50은 36.1 μg/mL로 나타났다. MTT reduction assay를 이용해 amyloid β protein (Aβ) 유도성 신경세포 독성에 대한 신경 세포 보호효과를 측정한 결과, 세 가지 마늘 추출물들은 대부분 40% 미만의 세포생존율을 보였고 이 결과는 Aβ 유도성 신경세포 독성보다 상대적으로 더 높은 세포독성을 보여주었다. LDH assay에 서는 마늘 물 추출물이 37%의 LDH 방출량을 나타내 200 μM의 vitamin C과 유사한 세포막손상 보 호효과를 보였다. 마지막으로 neutral red uptake assay를 실시한 결과, MTT reduction assay와 마찬가 지로 모든 마늘 추출물들에서 세포생존율의 감소를 확인하였으며 특히 디클로로메탄 추출물의 경우 현저하게 낮은 세포생존율을 나타내었다. AChE 저해활성을 갖는 마늘 디클로로메탄 추출물로부터 얻은 column fractionations에 함유된 생리활성물질을 탐색하기 위해 HPLC 분석을 실시하였으며, 마 늘 98:2 fraction의 LC-MS 분석을 통하여 allyl methyl disulfide, diallyl monosulfide, diallyl disulfide로 추정되는 물질군이 확인되었다.

본 논문에서는 시스템 연령(年齡)에 의해 보전 활동의 효과를 설명하는 일반 수리(修理) 개념을 이용한 최적 보전(保全) 정책에 대한 연구를 수행하였다. 본 논문에서는 주기적인 일반 수리와 고장 시 최소 수리가 적용되는 최적 보전 정책을 고려하였다. 따라서 일반 수리에 따른 보전 정책의 비용 함수를 도출하였고 최적 보전 정책을 도출하는 알고리즘을 제시하였고 예제를 통해 알고리즘의 성능을 분석하였다. 이 연구를 통해 시스템을 운영하는데 있어서 어느 수준의

The current electrical safety plan developed for the national electricity system has been playing an important role in handling a variety of electrical accidents. However, it can be more effective to prevent or reduce those accidents if a preventive electrical safety plan is available. In this paper, an approach to developing the safety plan is described. We first discuss the contents that should be included in the plan. Noting that an effective plan requires the system level consideration of all the factors affecting the safety issues, an operation concept document (OCD) is considered. The OCD can allow us to understand the behavior of the safety system based on the operation environment, the system functions, the performance requirements, all at the system level of the safety system. Thus, the OCD can be useful in developing the safety plan. A detailed description then follows on how the OCD is developed for the electrical safety system under study. Finally, we discuss how the developed OCD can be used in deriving the preventive electrical safety plan.

The purpose of this study was to investigate the preventive effects of Paeoniae Radix Extract (PRE) against the acute hepatotoxicity-inducing lipopolysaccharide (LPS) in the liver. PRE of 100 mg/kg concentration was intraperitoneally administered into rats at dose of 1.5 ml/kg for 20 days. On day 21, 5 mg/kg of LPS dissolved in saline was injected 4 hours before anesthetization. We examined the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), lactate dehydrogenase (LDH) in serum of rats, superoxide dismutase (SOD) in mitochondrial fractions, and malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPx) in liver homogenates. LPS-treatment markedly increased the levels of GOT, GPT, LDH and MDA, and significantly decreased those of SOD, CAT and GPx. But PRE-pretreatment decreased the levels of GOT, GPT, LDH and MDA, by 59.7%, 43.6%, 59.6% and 63.5%, respectively and increased those of SOD, CAT and GPx, by 85.5%, 57.8% and 62.9%, respectively. These results showed that the PRE had the preventive effects against the acute hepatotoxicityinducing LPS in the liver .

최근 우리 사회의 많은 관심 대상인 청소년 전자게임 중독 현황에 대하여 고찰하고, 이런 게임 중독으로 여러 사회문제를 야기 시켰다. 특히 우리 사회에서 거의 모든 청소년들은 게임을 즐기고 있다. (97.8%.게임백서 2006) 특히 한국사회에서 게임에 대한 본질적인 이해 부족으로 ‘청소년 게임 중독’에 대하여 학교나 가정에서 ‘억제’ 중심으로 접근하여 많은 갈등을 초래 하였다. 본 연구에서는 기존의 청소년 게임중독을 단순한 ‘차단’, ‘억제’ 중심인 ‘수동적’이고 ‘일방적’인 방법을 탈피하여 게임에 대한 올바른 이해와 교육을 통하여 우리의 미래인 청소년들에게 게임 중독에 대하여 ‘능동적’이고, 부모님과 선생님의 ‘상호작용’인 방법을 제안한다. 더욱이 우리사회의 전자게임 대한 인식이 ‘산업적’인 관점에서 탈피 하여 ‘문화적’인 매개로 접근을 제안한다. 전자게임 중독에 대한 예방 교육은 기존의 우리사회에서 전 자게임에 교육은 단순히 ‘게임인력 양성’중심에서 ‘게임 홍익인간 양성’으로 전자게임 에 대한 문화 교육의 제도화를 제안하여, 청소년 게임 중독에 대한 새로운 방안을 모색한다.

The purpose of the present study was examine the effects of group contingency management strategy in elementary school physical education setting on the problem of student managerial time for physical education class and to assess three subject teachers t

본 연구에서는 수컷 랫드에 DEHP를 투여하여 실험적으로 생식 독성을 유발하고, vitamin E와 catechin을 단독 및 병용 투여하여 수컷 랫드에서 정소의 조직학적 변화, 정액 특성의 변화 및 정자의 운동성 변화 등을 조사하여 그 예방 효과를 알아보고자 하였다. DEHP를 투여한 군은 대조군에 비해 정자농도, 정자 생존율, 정상 정자율이 감소하였다. DEHP에 의한 생식 독성을 예방하기 위해 vitamin E와 catechin을 단독 또는 병행

  This paper addresses a the maintenance system based on the concept of RAMS (Reliability, Availability, Maintenance, Safety) for the effective maintenance of the urban transit. A systematic approach for developing a cost-effective maintenance strategy ba

If done under this circumstances, then labor force can work comfortably and safely without nervousness and tiresome. The productivity and quality can increase ultimately and even foreign labor, imbecile child, old-aged labor can participate in work, which can reduce shortage of labor source. Therefore, in this study, it would be researched how to manage work blunder system by domestic small and medium enterprises and would be examined work blunder system was developed to fully meet the worker satisfaction. Through this 5M factor evaluation system by AHP(Analytic Hierarchy Process) all analyzed.

Objectives of this study is to develop suicide preventive correction program adapt to suicide-prone inmate. The suicide-preventive correction program applied to this study is composed of eight time tests because of peculiarity of correctional faculty. At first, regarding recognition card program, five participants in common showed gradually positivity to participate the program, and about 'feeling language', participants who use negative feeling language at first, use positive feeling language after the test. As scrutinizing the output measured from before and after the test, it is clear that melancholy, anxiety, stress, and self-respect of the subjects are improved. Among the subjects, 'vacant boat and non-singing bird' showed psychologic stability. But, It is shown that 'tree' was relatively less affect from the program, and 'pinetree' who arouse our interest from the start, could not be observed because of transportation to another place. As we know from this study, it is clear that in correctional faculty, regarding inmates who has personal problem such as the suicide-prone, group-program is effective, but in certain case individual-program is more appropriate than group-program.

This paper deals with two forms of preventive replacement policy with minimal repair at failure. Those are, 1. the replacement policy I based on the cumulative operating time. 2. the replacement policy II based on the number of failures. The basic assumptions are; (1) the cost of minimal repair at failure is increasing with the number of failures since the last replacement, (2) the equipment fails stochastically with time.

Considering in view of China's low price and Japan's high technology, the most important point is the quality of product. To increase the comparative power internationally all workingmen have to fulfill the responsibility to maximize the quality, and this is possible practiced under 'Zero Defect' spirit. To reduce the defect ratio to 'Zero' the workingmen have to recognize own fault, all the manufacturing process should be conducted under 'Fool Proof System', If done under this circumstances, then labor force can work comfortably and safely without nervousness and tiresome. The productivity and quality can increase ultimately and even foreign labor, imbecile child, old-aged labor can participate in work, which can reduce shortage of labor source. Therefore, in this study all defects in manufacturing process, it would be recognized the errors and mistakes caused by human.

Many countries of the world is driving forward development of large-scale hub port. They are now pushing ahead with setting up of effective marketing strategies to survive in keen competitions of the 21st century port industry. The port is of ever increasing importance for the bridge connecting sea and road transportation in handling international cargoes. The port, differently from general working places, is a closed area required for security, customs, and quarantine procedures. The loading and unloading is being done differently by ports, cargoes, and ships. To do loading and unloading, a lot of equipment and different types of labor are required, which flow is complicated and safe management is essential. As above mentioned the port is very unique and very deteriorated working place in its working environment. The purpose of this study is to propose ways to reduce and prevent from port accidents. As first step to do this, we have collected 923 accidents happened at Incheon Port during the period of 1994 to 2003. We have thoroughly analyzed characteristics, harmfulness, and risk of the loading/unloading they have done, as well as the accident frequency and relationship between the accidents. As second step to further analyze, We have employed DMAIC technology, an advanced process of 6 sigma presently in spotlight as the best program for management innovation. This analysis results in recognition of important accident characteristics, causes and effects analysis, critical causes of accident, and suggestions to decrease accidents.

TPM(Total Productive Management) that is enforcing introducing more than 80% in domestic manufacturing industry is using total plant efficiency by the evaluation index, and as a result, can see a lot of examples that plant productivity is increased. This study's purpose centers total productive management activities that is management system for total plant efficiency's maximization, plant information system that total productive management activities factor that is enforcing in manufacturing industry can develop evaluation model that can evaluate qualitative activities by quantitative activities in process that maximize total plant efficiency wishes to do design.

Many countries of the world is driving forward development of large-scale hub port. They are now pushing ahead with setting up of effective marketing strategies to survive in keen competitions of the 21st century port industry. The port is of ever increasing importance for the bridge connecting sea and road transportation in handling international cargoes. The port, differently from general working places, is a closed area required for security, customs, and quarantine procedures. The loading and unloading is being done differently by ports, cargoes, and ships. To do loading and unloading, a lot of equipment and different types of labor are required, which flow is complicated and safe management is essential. As above mentioned the port is very unique and very deteriorated working place in its working environment. The purpose of this study is to propose ways to reduce and prevent from port accidents. As first step to do this, we have collected 923 accidents happened at Incheon Port during the period of 1994 to 2003. We have thoroughly analyzed characteristics, harmfulness, and risk of the loading/unloading they have done, as well as the accident frequency and relationship between the accidents. As second step to further analyze, We have employed DMAIC technology, an advanced process of 6 sigma presently in spotlight as the best program for management innovation. This analysis results in recognition of important accident characteristics, causes and effects analysis, critical causes of accident, and suggestions to decrease accidents.

This study deals with the procedure of safety improvement, productivity increase ,and tact-time reduction through setting up the system about preventive maintenance. Actually, it is hard to establish and carry out preventive maintenance, even though we recognize the importance of the system concerning time, cost, labor, and so forth. In this study in the viewpoint of cost we are for achieving maximum efficiency by change and reduction of planning process adapted to the special work group. At first we briefly will mention the kind ,the necessity ,and the concept of preventive maintenance ,and then divide the equipment used in the assembly line into the two whether it is necessary or not by way of estimating the breakdown loss ,comparing with general establishment of preventive maintenance and modifying it to the case. At the second step we will establish the operation system of plan management related to production and quality in the special case. Check period and category will be set by dividing the assembly equipment into LCL and Focus in the third step. The forth step will contain the operation procedure in detail. And then we must make check and repair record periodically. Finally, on the basis of the record the selection of checking of significance will be conducted. This results in safety improvement, tact time reduction, and productivity improvement.

This study deals with the procedure of safety improvement, productivity increase, and tact-time reduction through setting up the system about preventive maintenance. Actually, it is hard to establish and carry out preventive maintenance, even though we recognize the importance of the system concerning time, cost, labor, and so forth. In this study in the viewpoint of cost we are for achieving maximum efficiency by change and reduction of planning process adapted to the special work group. At first we briefly will mention the kind, the necessity, and the concept of preventive maintenance, and then divide the equipment used in the assembly line into the two whether it is necessary or not by way of estimating the breakdown loss, comparing with general establishment of preventive maintenance and modifying it to the case. At the second step we will establish the operation system of plan management related to production and quality in the special case. Check period and category will be set by dividing the assembly equipment into LCL and Focus in the third step. The forth step will contain the operation procedure in detail. And then we must make check and repair record periodically. Finally, on the basis of the record the selection of checking of significance will be conducted. This results in safety improvement, tact time reduction, and productivity improvement.

The type of accidents associated with the operation of a melting facility for radioactive metal waste is assumed to only marginally differ from those associated with similar activities in the conventional metal casting industry or the current waste melting facility. However, the radiological consequences from a mishap or a technical failure differ widely. Three critical and at the same time possible accidents were identified: (1) activity release due to vapor explosion, (2) activity release due to ladle breakthrough, (3) consequences of failure in the hot-cell or furnace chamber not possible to remedy using remote equipment.

최근 공공시설물의 노후화에 따른 사회문제가 빈번하게 발생하고 있으며, 이에 따라 시설물에 대한 국민의 불안감도 증가 하고 있다. 향후 10년 내에 급증하게 되는 시설물 노후화 문제의 효과적인 대응을 위해 현재의 사후적인 유지관리에서 예측을 통한 선제적 유지관리로의 패러다임 전환이 시급한 실정이다. 본 연구에서는 빅데이터 시범분석을 통해서 교량, 터널, 공공건축물 일부에 대해 FMS 축적된 유지관리 데이터를 활용하여 지역별·환경별·공용년수별 취약요소를 도출하였고, Social Media의 비정형 데이터 분석을 통해 국민이 체감하는 불안/불편요소를 도출하였다. 또한 교량 취약요소의 손상발생패턴 분석을 통해 향후 선제적으로 관리해야 하는 유지관리 항목 및 추가적으로 확보해야 하는 디지털 정보 등을 제안하였다.

Structures are currently a good condition in highway, with an average age of 14.7years. However, After 10 years, The old structure will be estimated 22% of the total structure. In this study, We have suggested the preventive maintenance methods such as preventive techniques and asset management for the deterioration of future by a lesson of failure cases of developed countries such as the United States.

Gochujang, a traditional Korean food, is fermented by mixing red pepper powder, various grain, meju and salt. Changes in the kind of ingredients and fermentation method could increase health functionalities. In this study, in vivo anti-colitis effects of gochujang prepared with mixed grains, bamboo salt baked 3 times and meju starters on DSS-induced colitis in C57BL/6 mice were studied. We prepared gochujang prepared with mixed grains (MG), bamboo salt, and Aspergillus oryzae (A) and Baccillus subtilis (B) mixed starters (MG-AB) and gochujang prepared with MG, bamboo salt and A, B and Lactobacillus plantarum (L) mixed starters (MG-ABL). MG-AB and MG-ABL significantly increased body weight and colon length compared to the control (p<0.05). MG-ABL showed significantly decreased interleukin-6 (IL-6) expression in serum compared to the control and MG-AB group (p<0.05). MG-ABL also regulated mRNA and protein levels of pro-apoptotic Bcl-2-associated X protein (Bax) and anti-apoptotic B-cell lymphoma-2 (Bcl-2) in the mice colon tissue (p<0.05). Therefore, MG-ABL exhibited the increased anticolitis effects by inhibiting damage of colon tissue, probably by regulating a pro-inflammatory cytokine of IL-6 and regulated apoptosis related genes. These results indicated that gochujang changed with good ingredients and starters had colitis preventive effects and might be due to active compounds in mixed grain and bamboo salt, and produced by L during the fermentation of gochujang.

현재 미세먼지에 대한 화재가 점점 사람들의 시선을 끌고 있다. 미세먼지는 눈으로 볼 수 없 는 직경이 2.5μm(마이크로미터)인 먼지이며 폐 속 깊숙이 침투 할 수 있어 건강에 많은 피해를 준다. 사람들은 예방법을 알면서도 실행에 옮기지 않는 것은 미세먼지 위험성의 인지도가 낮기 때문이다. 본 논문은 어린이 대상으로 미세먼지의 인위적 원인과 자연적 원인의 생성 요소와 미세먼지 예방요소에 대한 인지도를 향상시키기 위하여 <우마이 탈출>보드게임 개발하여 다수 의 어린에게 테스트를 진행하여 <우마이 탈출>보드게임의 교육적 효과에 대한 연구를 진행하 였다.

본 논문은 교량의 예방적 유지관리 효과를 생애주기비용 절감 측면에서 분석 하였다. 예방적 유지관리는 현재 실시되고 있는 대응 적 유지관리 전략과 대비 되는 유지관리 전략으로 교량의 열화지연을 통해 궁극적으로는 교량의 사용수명을 연장 시키며 생애주기비용을 절 감시키는 유지관리 전략이다. 이러한 예방적 유지관리 효과를 분석하기 위해 교량의 공용연수에 따른 건전도 점수 변화 모델과 FHWA 자료를 바탕으로 한 국내 고속도로 교량의 건전도 점수에 따른 보수·보강 비용 모델을 제시 하였다. 제시한 복수의 모델과 국내외 참고 문헌을 바탕으 로 제안된 예방적 유지관리 항목(청소와 도장)의 비용과 주기를 활용하여 사용수명 100년까지의 표준교량(1,730 m2/교량) 당 생애주기 비용과 향후 20년간의 고속도로 총 유지관리 비용을 산정 하였다. 분석 결과 100년간 예방적 유지관리 활동으로 인해 교량 당 5억원의 절감효과를 볼 수 있으며 현재 예방적 유지관리 활동을 실시할 경우 20년 후(2035년)에는 총 1,837억원, 즉 연간 약 92억원의 비용 절감효과를 볼 수 있는 것으 로 분석 되었다.

선박, 항해기술 발달과 더불어 안전에 대한 교육 및 법제 강화에도 불구하고 해양사고는 지속적으로 발생하여 큰 피해를 주고 있 다. 사고가 발생하면 생명, 재산 그리고 환경적 재해가 수반하게 되므로 예방활동이 강조되고 그를 위한 정책적, 교육적, 법제적 노력에도 예 방성과는 미흡한 실정이다. 본 논문에서는 예방활동의 동기와 성과를 촉진하고 체계적인 안전관리를 위한 시각적이고 정량적인 지수를 개발 하여 선순환적인 예방문화를 구축하고자 선박사고 예방지수(PISA)와 예방수준(PLSA)을 개념화하고 정량화하였다. 선박사고 예방지수를 설 계하기 위하여 지난 5년(2009∼2013)간 국내에서 발생한 사고통계 자료를 4개 영역, 즉 교육, 기술, 단속, 정보영역으로 구조화하고 예방요소 와 인자를 추출함으로써 지수를 정의하였다. 정의된 지수 산정에 필요한 평가모듈을 설계하였으며, 설계된 모듈을 이용하여 화물선, 여객선, 유조선, 예선, 어선을 대상으로 지수를 측정하였다. 측정된 선박사고 예방지수 결과를 통계적, 사례적으로 위험성(Risk)과의 상관관계를 분석 하여 유용성을 확인하였다. 제안된 선박사고 예방지수를 인증제도 등에 활용함으로써 선박별 맞춤형 성과기반 예방활동은 물론 예방중심의 안전문화 촉진과 선박사고 저감효과가 기대된다.

컨테이너터미널에서 사용되는 컨테이너 크레인은 컨테이너 선박의 컨테이너를 양적하하는 주요 장비이다. 크레인이 고장이 나면, 컨테이너터미널의 생산성을 감소시킬 것이다. 본 논문은 컨테이너 크레인에 대한 예방정비 일정을 다룬다. 컨테이너 크레인은 많은 부품으로 구성되고 3개의 모델을 사용하여 컨테이너 크레인의 구조를 분석한다. 그리고 최적의 예방정비 일정을 결정하기 위하여 유전자 알고리즘을 적용하고 시뮬레이션 시스템을 통해서 제안된 방법의 성능을 평가한다. 마지막으로 작업일정에 기초하여 산업체에서 발견된 예방정비 일정을 조정하는 방법을 설명한다.

The preventive effects of sodium molybdate on the acute toxicity of lead were studied by investigating tissue accumulation of lead, changes of nerve conduction velocity and concentrations of metabolites related to function of sciatic nerve in rats treated with lead, sodium molybdate and both, respectively. In lead-intoxicated rat, the conduction velocity, myo-inositol concentration and Na+/K+ ATPase activity of sciatic nerve were decreased by about 33 %, 48 % and 58 %, respectively. However, sodium molybdate treatment significantly normalized the conduction velocity, Na+/K+ ATPase activity and myo-inositol concentration of sciatic nerve in lead-intoxicated rat. Also, sodium molybdate treatment decreased the contents of lead in blood and sciatic nerve through promotion of urinary excretion of lead. But sodium molybdate treatment did not affect the glucose concentration in sciatic nerve. These results suggest that sodium molybdate prevented peripheral neuropathy not only by reducing lead contents in sciatic nerve and blood, but also by enhancing Na+/K+ ATPase activity in sciatic nerve.

This study was to assess Korean sailors' knowldege, attitudes and behaviors about AIDS. The subjects of this study were 379 safety-trainee sailors. Data were collected by self reporting on a questionnaire during February to March 1996. The results were as follows : The mean score on AIDS knowledge was 17.3 out of a possible maximum score of 24.0. With respect to diseas transmission , only 45.6-86.5percent of the sailors correctly indicated that causal contact does not lead to contraction AIDS. The younger, unmarried , and educated groups had a higher level of knowledge about AIDS. With respect t sailors' attitudes about ADIS, 85.2 percent of the sailors reported that the AIDS is as big a problem as the media suggested, and over half of the sailors(53.8%) reported that they are being afraid of getting AIDS. One attitude, which was most pervasive(903.1 percent agreeing) was that it is important for sailors to receive AIDS education as a part of social education classes. In attitudes , there was statistical significance by age group, marital statistical signifiacance by age group , marital status, and educational level. With respect to sailor's preventive behaviors about AIDS, the mean score was 7.1 out of a possible maximum score of 9.0. It was shown that the older age, married groups had a higher level of preventive behaviors about AIDS.