간행물
대한구강악안면병리학회지 KCI 등재 The Korean Journal of Oral and Maxillofacial Pathology
- 발행기관 대한구강악안면병리학회
- 자료유형 학술지
- 간기 격월간
- ISSN 1225-1577 (Print)2384-0900 (Online)
- 수록기간 1977 ~ 2025
- 주제분류 의약학 > 치의학 의약학 분류의 다른 간행물
- 십진분류KDC 515DDC 610
권호리스트/논문검색
제49권 제6호 (2025년 12월) 8건
1.
2025.12
구독 인증기관 무료, 개인회원 유료
This study aimed to elucidate the functional correlation between G-protein activation and Ca²⁺ signaling during hypotonic shock-induced cell swelling in human osteoblast-like cells. Calcium influx was investigated using fura-2 fluorescence imaging, specific channel blockers, and G-protein modulators such as cholera toxin (CTX) and pertussis toxin (PTX). The external solution contained hypotonic Na⁺, and 300 M Cd²⁺ was applied to assess the involvement of extracellular Ca²⁺ channels. Calcium influx was significantly inhibited by Cd²⁺, indicating an extracellular source of Ca²⁺ through specific channels. CTX prolonged the hypotonic Na⁺-induced elevation of intracellular Ca²⁺, while PTX completely abolished it. These results suggest the involvement of G-protein-mediated pathways in Ca²⁺ regulation. Furthermore, the CTX-induced potentiation implies regulation via the cAMP/protein kinase A signaling axis, indicating that stretch sensitivity may be modulated by hormone-activated adenylate cyclase. This study is the first to demonstrate a functional link between hypotonic stress-induced Ca²⁺ influx and G-protein activation in human osteoblast-like cells, potentially involving a novel Ca²⁺ channel regulated by the cAMP/PKA pathway.
4,000원
2.
2025.12
구독 인증기관 무료, 개인회원 유료
This study investigated the anticancer efficacy and underlying mechanism of Sargassum pallidum (S. pallidum) extract and evaluated its potential as a natural therapeutic candidate against oral squamous cell carcinoma (OSCC). To assess its cytotoxic and antiproliferative effects, human OSCC cell lines were treated with varying concentrations of S. pallidum extract. The extract significantly inhibited cell viability and proliferation in a dose-dependent manner. Moreover, treatment with S. pallidum extract induced DNA damage, evidenced by increased γH2AX protein expression and nuclear foci formation. This DNA damage subsequently triggered apoptosis, as indicated by increased levels of the proapoptotic protein Bak and decreased levels of the antiapoptotic protein BCL-2. Furthermore, terminal deoxynucleotidyl transferase dUTP nick-end labeling assay results confirmed apoptotic DNA fragmentation following treatment. Collectively, these findings demonstrate that S. pallidum extract suppresses OSCC cell viability and proliferation by inducing DNA damage–mediated apoptosis, highlighting its potential as a natural anticancer agent in OSCC therapy.
4,000원
3.
2025.12
구독 인증기관 무료, 개인회원 유료
KX-01 (KX2-391or Tirbanibulin) is a reversible small-molecule inhibitor that binds to the colchicine-binding site of β-tubulin, leading to transient inhibition of microtubule polymerization. Although KX-01 has exhibited favorable pharmacologic properties and low toxicity in several epithelial malignancies, its therapeutic potential in salivary gland mucoepidermoid carcinoma (MEC) remains undefined. In this study, MC3 and YD15 MEC cells were exposed to KX-01 to assess its antitumor activity. Cell viability, anchorage-independent growth, and apoptotic morphology were examined using trypan blue exclusion, soft agar, and DAPI staining assays. Flow cytometric and immunoblot analyses were performed to quantify apoptotic cell populations and associated molecular markers. KX-01 treatment profoundly suppressed cell viability and colony formation, induced chromatin condensation and nuclear fragmentation, and markedly increased Annexin V–positive and sub-G1 populations. Furthermore, its enhanced cleavage of PARP and cleaved caspase-3. Collectively, these findings demonstrate that KX-01 exerts potent cytotoxic effects in MEC by triggering apoptotic pathway, supporting its further development as a targeted therapeutic candidate for human salivary MEC.
4,000원
4.
2025.12
구독 인증기관 무료, 개인회원 유료
Aging is strongly linked to mitochondrial dysfunction, which disrupts energy metabolism and tissue homeostasis. The salivary gland is an energy-dependent organ, and mitochondrial decline contributes to age-related atrophy and impaired secretion. In this study, we investigated whether spermidine can restore mitochondrial function in aging salivary glands. In aging accelerated klotho deficient mouse, spermidine supplementation improved glandular histology, restoring acinar organization and reducing atrophy. Transcriptomic profiling revealed that spermidine induced extensive transcriptional reprogramming, characterized by the upregulation of mitochondrial metabolic pathways and suppression of inflammatory signaling. qRT-PCR and Western blot analyses confirmed increased expression of PPARγ mediated mitochondrial membrane potential such as PGC-1α, NRF1/2, and OXPHOS complex subunits. Furthermore, spermidine elevated mitochondria oxygen consumption rate, including basal respiration, ATP production, maximal respiration, and spare respiratory capacity. These results demonstrated that spermidine improves mitochondria respiratory capacity through activation of the PPAR–PGC-1α–NRF regulatory axis and may serve as a potential therapeutic strategy for restoring mitochondrial homeostasis and preserving salivary gland function during aging.
4,500원
5.
2025.12
구독 인증기관 무료, 개인회원 유료
Oral verruciform xanthoma (OVX) is a rare benign lesion of the oral mucosa that typically presents as a small, well-circumscribed, papillary or verrucous plaque. Although its clinical appearance may pose diagnostic challenges, its histopathologic features – papillary or verrucous epithelial hyperplasia and the accumulation of lipid-laden foamy macrophages within the connective tissue papillae – are distinctive. In this study, we report an unusually large OVX arising from the mandibular gingiva and exhibiting destructive intraosseous extension. In addition, we analyze 28 cases with respect to clinical variables (age, sex, location, medical and dental history, and follow-up period) and histopathologic features (architectural type, degree of inflammation, predominant inflammatory cell type) Clinically, among 28 patients (18 males, 10 females; mean age 49.2 ± 15.1 years), the gingiva was the most commonly affected site (89%), followed by the tongue (11%). Autoimmune disease and malignancy were each identified in two patients (7%). Prosthesis-associated lesions occurred in four patients (14%). The mean clinical follow-up period was 10.0 months (available for 12 patients). Reappearance of OVX was noted in four cases with a mean interval of 20.5 months after the first excision. Histologically, OVXs were classified as verrucous type (61%) or papillary type (39%). The degree of inflammation was graded as mild in 10 cases (36%), moderate in 16 (57%), and severe in 2 (7%). Lymphocytes (75%) were the most frequent inflammatory cells, whereas plasma cells (21%) and neutrophils (4%) were occasionally admixed. This study highlights an uncommon biologic behavior of OVX and underscores practical importance of complete removal and histopathologic evaluation.
4,000원
6.
2025.12
구독 인증기관 무료, 개인회원 유료
Synovial chondromatosis is a rare benign metaplastic disorder of the synovial membrane, characterized by the formation of multiple cartilaginous nodules within the joint cavity. Involvement of the temporomandibular joint (TMJ) is particularly uncommon and often presents with clinical features that closely resemble internal derangement or osteoarthritis, frequently resulting in diagnostic delay and inappropriate management. Recognizing the distinctive clinical, radiologic, and histopathological characteristics of synovial chondromatosis is essential for accurate and timely diagnosis. In this report, we review the features of synovial chondormatosis of the TMJ and describe a case involving a 73-year-old female who presented with pain during mastication without limitation of mouth opening. Radiologic examination demonstrated multiple calcified nodules within the left TMJ space. Given the wide range of TMJ-related pathologies, such as myofascial pain and degenerative changes, which often present with similar symptoms, the identification of characteristic imaging and histopathologic findings is crucial for distinguishing synovial chondromatosis from other TMJ disorders and ensuring appropriate treatment. Through presentation of our clinical observations and a review of relevant literature, we aim to assist clinicians in recognizing synovial chondroamtosis of the TMJ and avoiding misdiagnosis, thereby facilitating prompt and effective patient care.
4,000원
7.
2025.12
구독 인증기관 무료, 개인회원 유료
Primary intraosseous carcinoma (PIOC) is a rare malignant odontogenic epithelial neoplasm arising within the jawbone, without connection to the oral mucosa or evidence of pre-existing malignancy. As PIOC often develops from odontogenic cysts, its clinical and radiographic features may closely mimic those of benign cystic lesions, making pre-operative diagnosis difficult and leading to delayed or inadequate treatment. This case report highlights the importance of careful assessment of subtle clinical, radiographic or intra-operative abnormalities, as well as the necessity of routine histopathologic examination.
4,000원
8.
2025.12
구독 인증기관 무료, 개인회원 유료
Vascular malformations comprise a spectrum of structural anomalies of blood vessels that may present with variable symptoms and clinical behavior. Among these, venous malformations are the most common low-flow lesions and can involve both cutaneous and mucosal tissues. However, intraoral venous malformations, particularly those arising in the buccal mucosa, are uncommon and may be misdiagnosed as other benign oral lesions. In such cases, subtle clinical findings and nonspecific symptoms can delay diagnosis and appropriate management. Imaging modalities, including Doppler ultrasonography and magnetic resonance imaging, are useful for confirming the low-flow nature of the lesion, delineating its extent, and distinguishing it from other vascular anomalies or soft tissue masses. Therapeutic options range from observation to sclerotherapy, laser treatment, or surgical excision, and must be adapted according to lesion size, location, and symptom burden. This report describes a low-flow venous malformation of the buccal mucosa and outlines the clinical, radiologic, and therapeutic considerations relevant to this rare presentation in the head and neck region. By presenting this case and reviewing the pertinent literature, we aim to raise awareness of buccal venous malformations and provide practical guidance for their evaluation and management.
4,000원
